Angiogenesis in Non-Hodgkin's Lymphoma : An Intercategory Comparison of Microvessel Density
المؤلفون المشاركون
Singh, Sompal
Pant, Leela
Srivastava, Gunjan
Krishan, Gopal
Aggarwal, Deepti
Gupta, Ruchika
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-27
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
This study was aimed at comparing angiogenesis, seen as microvessel density (MVD) in subtypes of non-Hodgkin’s lymphoma (NHL).
Methods.
In this study, 64 cases of NHL diagnosed over a three-year period were included along with 15 lymph node biopsies of reactive hyperplasia.
NHLs were classified using REAL classification, and immunohistochemistry was performed for CD34 in all cases.
CD34-stained sections were evaluated for “hot spots,” where MVD was assessed and expressed as per mm2.
Appropriate statistical methods were applied.
Results.
There were 6 cases of well-differentiated lymphocytic lymphoma (SLL), 21 diffuse large B-cell lymphoma (DLBCL), 15 follicular lymphoma, 10 lymphoblastic lymphoma, 7 MALToma, and 5 peripheral T-cell lymphoma (PTCL).
Mean MVD was highest in reactive hyperplasia (191.92±12.16 per mm2) compared to all NHLs.
Among NHLs, PTCL demonstrated the highest MVD (183.42±8.24) followed by DLBCL (149.91±13.68).
A significant difference was found in MVD between reactive and individual lymphoma groups.
SLL had significantly lower MVD than other lymphoma subtypes.
Conclusion.
Angiogenesis, assessed by MVD, showed significant differences among subtypes of NHL, especially the indolent types like SLL.
The higher MVD in aggressive lymphomas like PTCL and DLBCL can potentially be utilized in targeted therapy with antiangiogenic drugs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aggarwal, Deepti& Srivastava, Gunjan& Gupta, Ruchika& Pant, Leela& Krishan, Gopal& Singh, Sompal. 2012. Angiogenesis in Non-Hodgkin's Lymphoma : An Intercategory Comparison of Microvessel Density. ISRN Hematology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-510172
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aggarwal, Deepti…[et al.]. Angiogenesis in Non-Hodgkin's Lymphoma : An Intercategory Comparison of Microvessel Density. ISRN Hematology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-510172
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aggarwal, Deepti& Srivastava, Gunjan& Gupta, Ruchika& Pant, Leela& Krishan, Gopal& Singh, Sompal. Angiogenesis in Non-Hodgkin's Lymphoma : An Intercategory Comparison of Microvessel Density. ISRN Hematology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-510172
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510172
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر