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Butein Inhibits Angiogenesis of Human Endothelial Progenitor Cells via the Translation Dependent Signaling Pathway
المؤلفون المشاركون
Chang, Chien-Hsin
Wang, Shih-Wei
Yeh, Hung-I
Wang, Hsueh-Hsiao
Wu, Nan-Lin
Hsiao, Che-Jen
Chen, Shiou-Sheng
Wang, Po-Chuan
Yen, Juei-Yu
Huang, Tur-Fu
Chung, Ching-Hu
Chen, Yen-Ling
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-06
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Compelling evidence indicates that bone marrow-derived endothelial progenitor cells (EPCs) can contribute to postnatal neovascularization and tumor angiogenesis.
EPCs have been shown to play a “catalytic” role in metastatic progression by mediating the angiogenic switch.
Understanding the pharmacological functions and molecular targets of natural products is critical for drug development.
Butein, a natural chalcone derivative, has been reported to exert potent anticancer activity.
However, the antiangiogenic activity of butein has not been addressed.
In this study, we found that butein inhibited serum- and vascular endothelial growth factor- (VEGF-) induced cell proliferation, migration, and tube formation of human EPCs in a concentration dependent manner without cytotoxic effect.
Furthermore, butein markedly abrogated VEGF-induced vessels sprouting from aortic rings and suppressed microvessel formation in the Matrigel implant assay in vivo.
In addition, butein concentration-dependently repressed the phosphorylation of Akt, mTOR, and the major downstream effectors, p70S6K, 4E-BP1, and eIF4E in EPCs.
Taken together, our results demonstrate for the first time that butein exhibits the antiangiogenic effect both in vitro and in vivo by targeting the translational machinery.
Butein is a promising angiogenesis inhibitor with the potential for treatment of cancer and other angiogenesis-related diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chung, Ching-Hu& Chang, Chien-Hsin& Chen, Shiou-Sheng& Wang, Hsueh-Hsiao& Yen, Juei-Yu& Hsiao, Che-Jen…[et al.]. 2013. Butein Inhibits Angiogenesis of Human Endothelial Progenitor Cells via the Translation Dependent Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-510186
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chung, Ching-Hu…[et al.]. Butein Inhibits Angiogenesis of Human Endothelial Progenitor Cells via the Translation Dependent Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-510186
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chung, Ching-Hu& Chang, Chien-Hsin& Chen, Shiou-Sheng& Wang, Hsueh-Hsiao& Yen, Juei-Yu& Hsiao, Che-Jen…[et al.]. Butein Inhibits Angiogenesis of Human Endothelial Progenitor Cells via the Translation Dependent Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-510186
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510186
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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