IL-17 in Systemic Lupus Erythematosus

الملخص EN

IL-17 is a cytokine with powerful proinflammatory activity.

Production of IL-17 is abnormally increased in patients with systemic lupus erythematosus (SLE), a multiorgan chronic autoimmune disease.

In patients with SLE, CD3+CD4−CD8− (double negative) T cells are an important source of IL-17.

IL-17 produced by double negative and CD4 T cells participates in the pathogenesis of the disease.

IL-17-producing T cells are present in the kidneys of patients with lupus nephritis.

IL-17 increased production in patients with SLE can amplify the immune response by increasing target organ inflammation and damage and by augmenting the production of antibodies by B cells.