Renal and Vascular Mechanisms of Thiazolidinedione-Induced Fluid Retention

المؤلفون المشاركون

Yang, Tianxin
Soodvilai, Sunhapas

المصدر

PPAR Research

العدد

المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2008-09-07

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء

الملخص EN

Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor subtype γ (PPARγ) activators that are clinically used as an insulin sensitizer for glycemic control in patients with type 2 diabetes.

Additionally, TZDs exhibit novel anti-inflammatory, antioxidant, and antiproliferative properties, indicating therapeutic potential for a wide variety of diseases associated with diabetes and other conditions.

The clinical applications of TZDs are limited by the common major side effect of fluid retention.

A better understanding of the molecular mechanism of TZD-induced fluid retention is essential for the development of novel therapies with improved safety profiles.

An important breakthrough in the field is the finding that the renal collecting duct is a major site for increased fluid reabsorption in response to rosiglitazone or pioglitazone.

New evidence also indicates that increased vascular permeability in adipose tissues may contribute to edema formation and body weight gain.

Future research should therefore be directed at achieving a better understanding of the detailed mechanisms of TZD-induced increases in renal sodium transport and in vascular permeability.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Yang, Tianxin& Soodvilai, Sunhapas. 2008. Renal and Vascular Mechanisms of Thiazolidinedione-Induced Fluid Retention. PPAR Research،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-510215

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Yang, Tianxin& Soodvilai, Sunhapas. Renal and Vascular Mechanisms of Thiazolidinedione-Induced Fluid Retention. PPAR Research No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-510215

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Yang, Tianxin& Soodvilai, Sunhapas. Renal and Vascular Mechanisms of Thiazolidinedione-Induced Fluid Retention. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-510215

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-510215