Sunflower Oil Supplementation Has Proinflammatory Effects and Does Not Reverse Insulin Resistance in Obesity Induced by High-Fat Diet in C57BL6 Mice
المؤلفون المشاركون
Martins, Amanda Roque
Neto, José César Rosa
Amaral, Cátia Lira do
Curi, Rui
Masi, Laureane Nunes
Vinolo, Marco Aurélio Ramirez
Crisma, Amanda Rabello
de Lima Júnior, Edson Alves
Hirabara, Sandro Massao
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
High consumption of polyunsaturated fatty acids, such as sunflower oil has been associated to beneficial effects in plasma lipid profile, but its role on inflammation and insulin resistance is not fully elucidated yet.
We evaluated the effect of sunflower oil supplementation on inflammatory state and insulin resistance condition in HFD-induced obese mice.
C57BL/6 male mice (8 weeks) were divided in four groups: (a) control diet (CD), (b) HFD, (c) CD supplemented with n-6 (CD + n-6), and (d) HFD supplemented with n-6 (HFD + n-6).
CD + n-6 and HFD + n-6 were supplemented with sunflower oil by oral gavage at 2 g/Kg of body weight, three times per week.
CD and HFD were supplemented with water instead at the same dose.
HFD induced whole and muscle-specific insulin resistance associated with increased inflammatory markers in insulin-sensitive tissues and macrophage cells.
Sunflower oil supplementation was not efficient in preventing or reducing these parameters.
In addition, the supplementation increased pro-inflammatory cytokine production by macrophages and tissues.
Lipid profile, on the other hand, was improved with the sunflower oil supplementation in animals fed HFD.
In conclusion, sunflower oil supplementation improves lipid profile, but it does not prevent or attenuate insulin resistance and inflammation induced by HFD in C57BL/6 mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Masi, Laureane Nunes& Martins, Amanda Roque& Neto, José César Rosa& Amaral, Cátia Lira do& Crisma, Amanda Rabello& Vinolo, Marco Aurélio Ramirez…[et al.]. 2012. Sunflower Oil Supplementation Has Proinflammatory Effects and Does Not Reverse Insulin Resistance in Obesity Induced by High-Fat Diet in C57BL6 Mice. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-510260
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Masi, Laureane Nunes…[et al.]. Sunflower Oil Supplementation Has Proinflammatory Effects and Does Not Reverse Insulin Resistance in Obesity Induced by High-Fat Diet in C57BL6 Mice. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-510260
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Masi, Laureane Nunes& Martins, Amanda Roque& Neto, José César Rosa& Amaral, Cátia Lira do& Crisma, Amanda Rabello& Vinolo, Marco Aurélio Ramirez…[et al.]. Sunflower Oil Supplementation Has Proinflammatory Effects and Does Not Reverse Insulin Resistance in Obesity Induced by High-Fat Diet in C57BL6 Mice. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-510260
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510260
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر