The Effect of Cold Ischemia Time andor Formalin Fixation on Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor-2 Results in Breast Carcinoma
المؤلفون المشاركون
Pekmezci, Melike
Osipo, Clodia
Erşahin, Çağatay
Szpaderska, Anna
المصدر
Pathology Research International
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-11
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aims.
To compare the results of estrogen and progesterone receptors (ER, PR), and human epidermal growth factor receptor-2 (HER2) expression status on biopsy and excision specimens and to evaluate the effect of cold ischemia time and/or formalin fixation on these biomarkers.
Methods.
Breast carcinomas that were diagnosed between 2007 and 2009 by core needle biopsy, and subsequently excised in our institution, were included in the study.
Data regarding the tumor morphology, grade, and ER, PR, and HER2 status were retrospectively collected from the pathology reports.
Results.
Five out of 149 (3.4%) cases with ER-positive receptor status in the biopsy specimen became ER-negative in the subsequent excision specimen.
Nine out of 126 (7.1%) cases with PR-positive receptor status in the biopsy specimen became PR-negative in the excision specimen.
Receptor status change was predominantly seen in tumors with low ER and PR receptor expression.
HER2 results were consistent between biopsy and excision specimens in all cases tested.
Conclusions.
Cold ischemia time and/or formalin fixation affect mainly ER and PR testing with low Allred scores and support the implementation of the ASCO/CAP guidelines.
HER2 results, however, were not affected in our limited number of patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pekmezci, Melike& Szpaderska, Anna& Osipo, Clodia& Erşahin, Çağatay. 2012. The Effect of Cold Ischemia Time andor Formalin Fixation on Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor-2 Results in Breast Carcinoma. Pathology Research International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-510433
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pekmezci, Melike…[et al.]. The Effect of Cold Ischemia Time andor Formalin Fixation on Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor-2 Results in Breast Carcinoma. Pathology Research International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-510433
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pekmezci, Melike& Szpaderska, Anna& Osipo, Clodia& Erşahin, Çağatay. The Effect of Cold Ischemia Time andor Formalin Fixation on Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor-2 Results in Breast Carcinoma. Pathology Research International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-510433
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510433
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر