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iMethyl-PseAAC : Identification of Protein Methylation Sites via a Pseudo Amino Acid Composition Approach
المؤلفون المشاركون
Chou, Kuo-Chen
Xiao, Xuan
Qiu, Wang-Ren
Lin, Wei-Zhong
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-22
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Before becoming the native proteins during the biosynthesis, their polypeptide chains created by ribosome’s translating mRNA will undergo a series of “product-forming” steps, such as cutting, folding, and posttranslational modification (PTM).
Knowledge of PTMs in proteins is crucial for dynamic proteome analysis of various human diseases and epigenetic inheritance.
One of the most important PTMs is the Arg- or Lys-methylation that occurs on arginine or lysine, respectively.
Given a protein, which site of its Arg (or Lys) can be methylated, and which site cannot? This is the first important problem for understanding the methylation mechanism and drug development in depth.
With the avalanche of protein sequences generated in the postgenomic age, its urgency has become self-evident.
To address this problem, we proposed a new predictor, called iMethyl-PseAAC.
In the prediction system, a peptide sample was formulated by a 346-dimensional vector, formed by incorporating its physicochemical, sequence evolution, biochemical, and structural disorder information into the general form of pseudo amino acid composition.
It was observed by the rigorous jackknife test and independent dataset test that iMethyl-PseAAC was superior to any of the existing predictors in this area.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qiu, Wang-Ren& Xiao, Xuan& Lin, Wei-Zhong& Chou, Kuo-Chen. 2014. iMethyl-PseAAC : Identification of Protein Methylation Sites via a Pseudo Amino Acid Composition Approach. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-510475
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qiu, Wang-Ren…[et al.]. iMethyl-PseAAC : Identification of Protein Methylation Sites via a Pseudo Amino Acid Composition Approach. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-510475
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qiu, Wang-Ren& Xiao, Xuan& Lin, Wei-Zhong& Chou, Kuo-Chen. iMethyl-PseAAC : Identification of Protein Methylation Sites via a Pseudo Amino Acid Composition Approach. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-510475
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510475
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