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Xenogenic Esophagus Scaffolds Fixed with Several Agents : Comparative In Vivo Study of Rejection and Inflammation
المؤلفون المشاركون
Emmrich, Frank
Aupperle, Heike
Koch, Holger
Sack, Ulrich
Metzger, Roman
Graneist, Cora
Till, Holger
Schierle, Katrin
Boldt, Andreas
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-08
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Most infants with long-gap esophageal atresia receive an esophageal replacement with tissue from stomach or colon, because the native esophagus is too short for true primary repair.
Tissue-engineered esophageal conducts could present an attractive alternative.
In this paper, circular decellularized porcine esophageal scaffold tissues were implanted subcutaneously into Sprague-Dawley rats.
Depending on scaffold cross-linking with genipin, glutaraldehyde, and carbodiimide (untreated scaffolds : positive control; bovine pericardium : gold standard), the number of infiltrating fibroblasts, lymphocytes, macrophages, giant cells, and capillaries was determined to quantify the host response after 1, 9, and 30 days.
Decellularized esophagus scaffolds were shown to maintain native matrix morphology and extracellular matrix composition.
Typical inflammatory reactions were observed in all implants; however, the cellular infiltration was reduced in the genipin group.
We conclude that genipin is the most efficient and best tolerated cross-linking agent to attenuate inflammation and to improve the integration of esophageal scaffolds into its surrounding tissue after implantation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Koch, Holger& Graneist, Cora& Emmrich, Frank& Till, Holger& Metzger, Roman& Aupperle, Heike…[et al.]. 2012. Xenogenic Esophagus Scaffolds Fixed with Several Agents : Comparative In Vivo Study of Rejection and Inflammation. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-510556
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Koch, Holger…[et al.]. Xenogenic Esophagus Scaffolds Fixed with Several Agents : Comparative In Vivo Study of Rejection and Inflammation. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-510556
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Koch, Holger& Graneist, Cora& Emmrich, Frank& Till, Holger& Metzger, Roman& Aupperle, Heike…[et al.]. Xenogenic Esophagus Scaffolds Fixed with Several Agents : Comparative In Vivo Study of Rejection and Inflammation. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-510556
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510556
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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