A Study of Mechanical Optimization Strategy for Cardiac Resynchronization Therapy Based on an Electromechanical Model
المؤلفون المشاركون
Liu, Feng
Zang, Yunliang
Dou, Jianhong
Deng, Dongdong
Xia, Ling
Tu, Weifeng
Shou, Guofa
Bustos, Cesar
Crozier, Stuart
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-16
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
An optimal electrode position and interventricular (VV) delay in cardiac resynchronization therapy (CRT) improves its success.
However, the precise quantification of cardiac dyssynchrony and magnitude of resynchronization achieved by biventricular (BiV) pacing therapy with mechanical optimization strategies based on computational models remain scant.
The maximum circumferential uniformity ratio estimate (CURE) was used here as mechanical optimization index, which was automatically computed for 6 different electrode positions based on a three-dimensional electromechanical canine model of heart failure (HF) caused by complete left bundle branch block (CLBBB).
VV delay timing was adjusted accordingly.
The heart excitation propagation was simulated with a monodomain model.
The quantification of mechanical intra- and interventricular asynchrony was then investigated with eight-node isoparametric element method.
The results showed that (i) the optimal pacing location from maximal CURE of 0.8516 was found at the left ventricle (LV) lateral wall near the equator site with a VV delay of 60 ms, in accordance with current clinical studies, (ii) compared with electrical optimization strategy of ERMS, the LV synchronous contraction and the hemodynamics improved more with mechanical optimization strategy.
Therefore, measures of mechanical dyssynchrony improve the sensitivity and specificity of predicting responders more.
The model was subject to validation in future clinical studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dou, Jianhong& Xia, Ling& Deng, Dongdong& Zang, Yunliang& Shou, Guofa& Bustos, Cesar…[et al.]. 2012. A Study of Mechanical Optimization Strategy for Cardiac Resynchronization Therapy Based on an Electromechanical Model. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-510608
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dou, Jianhong…[et al.]. A Study of Mechanical Optimization Strategy for Cardiac Resynchronization Therapy Based on an Electromechanical Model. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-510608
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dou, Jianhong& Xia, Ling& Deng, Dongdong& Zang, Yunliang& Shou, Guofa& Bustos, Cesar…[et al.]. A Study of Mechanical Optimization Strategy for Cardiac Resynchronization Therapy Based on an Electromechanical Model. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-510608
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510608
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر