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Antinociceptive and Antioxidant Activities of Phytol In Vivo and In Vitro Models
المؤلفون المشاركون
Santos, Camila Carolina de Menezes Patrício
de Almeida, Antonia Amanda Cardoso
de Freitas, Rivelilson Mendes
Salvadori, Mirian Stiebbe
de Almeida, Reinaldo Nóbrega
de Oliveira, Guilherme Antônio Lopes
de Sousa, Damião Pergentino
Costa, Jéssica Pereira
Mota, Vanine Gomes
Costa, Luciana Muratori
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The objective of the present study was to evaluate the antinociceptive effects of phytol using chemical and thermal models of nociception in mice and to assess its antioxidant effects in vitro.
Phytol was administered intraperitoneally (i.p.) to mice at doses of 25, 50, 100, and 200 mg/kg.
In the acetic acid-induced writhing test, phytol significantly reduced the number of contortions compared to the control group (P<0.001).
In the formalin test, phytol reduced significantly the amount of time spent in paw licking in both phases (the neurogenic and inflammatory phases), this effect being more pronounced in the second phase (P<0.001).
Phytol also provoked a significant increase in latency in the hot plate test.
These antinociceptive effects did not impaire the motor performance, as shown in the rotarod test.
Phytol demonstrated a strong antioxidant effect in vitro in its capacity to remove hydroxyl radicals and nitric oxide as well as to prevent the formation of thiobarbituric acid reactive substances (TBARS).
Taken as a whole, these results show the pronounced antinociceptive effects of phytol in the nociception models used, both through its central and peripheral actions, but also its antioxidant properties demonstrated in the in vitro methods used.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Santos, Camila Carolina de Menezes Patrício& Salvadori, Mirian Stiebbe& Mota, Vanine Gomes& Costa, Luciana Muratori& de Almeida, Antonia Amanda Cardoso& de Oliveira, Guilherme Antônio Lopes…[et al.]. 2013. Antinociceptive and Antioxidant Activities of Phytol In Vivo and In Vitro Models. Neuroscience Journal،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-510660
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Santos, Camila Carolina de Menezes Patrício…[et al.]. Antinociceptive and Antioxidant Activities of Phytol In Vivo and In Vitro Models. Neuroscience Journal No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-510660
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Santos, Camila Carolina de Menezes Patrício& Salvadori, Mirian Stiebbe& Mota, Vanine Gomes& Costa, Luciana Muratori& de Almeida, Antonia Amanda Cardoso& de Oliveira, Guilherme Antônio Lopes…[et al.]. Antinociceptive and Antioxidant Activities of Phytol In Vivo and In Vitro Models. Neuroscience Journal. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-510660
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510660
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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