Garlic Oil Alleviates MAPKs- and IL-6-mediated Diabetes-related Cardiac Hypertrophy in STZ-induced DM Rats
المؤلفون المشاركون
Teng, Kun-Yu
Chen, Hong
Tsai, Fuu-Jen
Liu, Chung-Jung
Chang, Sheng-Huang
Chang, Sheng-Wei
Kuo, Wei-Wen
Tzang, Bor-Show
Tsai, Chang-Hai
Huang, Chih-Yang
Lin, Wen-Yuan
Kuo, Chia-Hua
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Garlic oil has been reported to protect the cardiovascular system; however, the effects and mechanisms behind the cardioprotection of garlic oil on diabetes-induced cardiaomyopathy are unclear.
In this study, we used streptozotocin (STZ)-induced diabetic rats to investigate whether garlic oil could protect the heart from diabetes-induced cardiomyopathy.
Wistar STZ-induced diabetic rats received garlic oil (0, 10, 50 or 100 mg kg−1 body weight) by gastric gavage every 2 days for 16 days.
Normal rats without diabetes were used as control.
Cardiac contractile dysfunction and cardiac pathologic hypertrophy responses were observed in diabetic rat hearts.
Cardiac function was examined using echocardiography.
In addition to cardiac hypertrophy-related mitogen-activated protein kinases (MAPK) pathways (e.g., p38, c-Jun N-terminal kinases (JNK) and extracellularly responsive kinase (ERK1/2)), the IL-6/MEK5/ERK5 signaling pathway was greatly activated in the diabetic rat hearts, which contributes to the up-regulation of cardiac pathologic hypertrophy markers including atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), and leads to cardiac contractile dysfunction.
Garlic oil treatment significantly inhibited the up-regulation in MAPK (e.g., p38, JNK and ERK1/2) and IL-6/MEK5/ERK5 signaling pathways in the diabetic rat hearts, reducing the levels of cardiac pathologic hypertrophy markers such as ANP and BNP, and improving the cardiac contractile function.
Collectively, data from these studies demonstrate that garlic oil shows the potential cardioprotective effects for protecting heart from diabetic cardiomyopathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Sheng-Huang& Liu, Chung-Jung& Kuo, Chia-Hua& Chen, Hong& Lin, Wen-Yuan& Teng, Kun-Yu…[et al.]. 2011. Garlic Oil Alleviates MAPKs- and IL-6-mediated Diabetes-related Cardiac Hypertrophy in STZ-induced DM Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-510702
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Sheng-Huang…[et al.]. Garlic Oil Alleviates MAPKs- and IL-6-mediated Diabetes-related Cardiac Hypertrophy in STZ-induced DM Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-510702
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Sheng-Huang& Liu, Chung-Jung& Kuo, Chia-Hua& Chen, Hong& Lin, Wen-Yuan& Teng, Kun-Yu…[et al.]. Garlic Oil Alleviates MAPKs- and IL-6-mediated Diabetes-related Cardiac Hypertrophy in STZ-induced DM Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-510702
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510702
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر