Multidisciplinary Pharmacotherapeutic Options for Nonalcoholic Fatty Liver Disease
المؤلف
المصدر
International Journal of Hepatology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-09
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Nonalcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are multidisciplinary liver diseases that often accompany type 2 diabetes or metabolic syndrome, which are characterized by insulin resistance.
Therefore, effective treatment of type 2 diabetes and metabolic syndrome should target not only the cardiometabolic abnormalities, but also the associated liver disorders.
In the last decade, it has been shown that metformin, thiazolidinediones, vitamin E, ezetimibe, n-3 polyunsaturated fatty acids, renin-angiotensin system (RAS) blockers, and antiobesity drugs may improve hepatic pathophysiological disorders as well as clinical parameters.
Accordingly, insulin sensitizers, antioxidative agents, Niemann-Pick C1-like 1 (NPC1L1) inhibitors, RAS blockers, and drugs that target the central nervous system may represent candidate pharmacotherapies for NAFLD and possibly NASH.
However, the efficacy, safety, and tolerability of long-term treatment (potentially for many years) with these drugs have not been fully established.
Furthermore, clinical trials have not comprehensively examined the efficacy of lipid-lowering drugs (i.e., statins, fibrates, and NPC1L1 inhibitors) for the treatment of NAFLD.
Although clinical evidence for RAS blockers and incretin-based agents (GLP-1 analogs and dipeptidyl peptidase-4 inhibitors) is also lacking, these agents are promising in terms of their insulin-sensitizing and anti-inflammatory effects without causing weight gain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nakajima, Kei. 2012. Multidisciplinary Pharmacotherapeutic Options for Nonalcoholic Fatty Liver Disease. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-510770
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nakajima, Kei. Multidisciplinary Pharmacotherapeutic Options for Nonalcoholic Fatty Liver Disease. International Journal of Hepatology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-510770
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nakajima, Kei. Multidisciplinary Pharmacotherapeutic Options for Nonalcoholic Fatty Liver Disease. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-510770
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510770
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر