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A Versatile Polymer Micelle Drug Delivery System for Encapsulation and In Vivo Stabilization of Hydrophobic Anticancer Drugs
المؤلفون المشاركون
Skaff, Habib
Rios-Doria, Jonathan
Sill, Kevin
Carie, Adam
Panicucci, Riccardo
Burke, Brian
Costich, Tara
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Chemotherapeutic drugs are widely used for the treatment of cancer; however, use of these drugs is often associated with patient toxicity and poor tumor delivery.
Micellar drug carriers offer a promising approach for formulating and achieving improved delivery of hydrophobic chemotherapeutic drugs; however, conventional micelles do not have long-term stability in complex biological environments such as plasma.
To address this problem, a novel triblock copolymer has been developed to encapsulate several different hydrophobic drugs into stable polymer micelles.
These micelles have been engineered to be stable at low concentrations even in complex biological fluids, and to release cargo in response to low pH environments, such as in the tumor microenvironment or in tumor cell endosomes.
The particle sizes of drugs encapsulated ranged between 30–80 nm, with no relationship to the hydrophobicity of the drug.
Stabilization of the micelles below the critical micelle concentration was demonstrated using a pH-reversible crosslinking mechanism, with proof-of-concept demonstrated in both in vitro and in vivo models.
Described herein is polymer micelle drug delivery system that enables encapsulation and stabilization of a wide variety of chemotherapeutic drugs in a single platform.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rios-Doria, Jonathan& Carie, Adam& Costich, Tara& Burke, Brian& Skaff, Habib& Panicucci, Riccardo…[et al.]. 2012. A Versatile Polymer Micelle Drug Delivery System for Encapsulation and In Vivo Stabilization of Hydrophobic Anticancer Drugs. Journal of Drug Delivery،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-510888
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rios-Doria, Jonathan…[et al.]. A Versatile Polymer Micelle Drug Delivery System for Encapsulation and In Vivo Stabilization of Hydrophobic Anticancer Drugs. Journal of Drug Delivery No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-510888
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rios-Doria, Jonathan& Carie, Adam& Costich, Tara& Burke, Brian& Skaff, Habib& Panicucci, Riccardo…[et al.]. A Versatile Polymer Micelle Drug Delivery System for Encapsulation and In Vivo Stabilization of Hydrophobic Anticancer Drugs. Journal of Drug Delivery. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-510888
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510888
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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