Investigations on Agglomeration and Haemocompatibility of Vitamin E TPGS Surface Modified Berberine Chloride Nanoparticles
المؤلفون المشاركون
Singh, Sanjay
Rajamanickam, Vijayakumar Mahalingam
Vuddanda, Parameswara Rao
Yaspal, Madhu
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The objective of the present study is to investigate the influence of surface modification on systemic stability of NPs.
Vitamin E TPGS (1% w/v) was used for surface modification of berberine chloride nanoparticles.
Naked and surface modified NPs were incubated in different SBFs (pH 6.8 and 7.4) with or without bile salts and human plasma.
NPs were observed for particle agglomeration and morphology by particle size analyzer and TEM, respectively.
The haemocompatibility studies were conducted on developed NPs to evaluate their safety profile.
The surface modified NPs were stable compared to naked NPs in different SBFs due to the steric stabilization property of vitamin E TPGS.
Particle agglomeration was not seen when NPs were incubated in SBF (pH 6.8) with bile salts.
No agglomeration was observed in NPs after their incubation in plasma but particle size of the naked NPs increased due to adhesion of plasma proteins.
The TEM images confirmed the particle size results.
DSC and FT-IR studies confirmed the coexistence of TPGS in surface modified NPs.
The permissible haemolysis, LDH release, and platelet aggregation revealed that NPs were compatible for systemic administration.
Thus, the study illustrated that the surface modification is helpful in the maintenance of stability of NPs in systemic conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vuddanda, Parameswara Rao& Rajamanickam, Vijayakumar Mahalingam& Yaspal, Madhu& Singh, Sanjay. 2014. Investigations on Agglomeration and Haemocompatibility of Vitamin E TPGS Surface Modified Berberine Chloride Nanoparticles. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-510906
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vuddanda, Parameswara Rao…[et al.]. Investigations on Agglomeration and Haemocompatibility of Vitamin E TPGS Surface Modified Berberine Chloride Nanoparticles. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-510906
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vuddanda, Parameswara Rao& Rajamanickam, Vijayakumar Mahalingam& Yaspal, Madhu& Singh, Sanjay. Investigations on Agglomeration and Haemocompatibility of Vitamin E TPGS Surface Modified Berberine Chloride Nanoparticles. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-510906
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510906
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر