The Characteristics and Significance of Locally Infiltrating B Cells in Lupus Nephritis and Their Association with Local BAFF Expression
المؤلفون المشاركون
Chen, Xiao-Wei
Shen, Yan
Dai, Ming
Yang, Cheng-De
Li, Ting
Sun, Chuan-Yin
Wu, Feng-Xia
Yan, Yu-Cheng
المصدر
International Journal of Rheumatology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Introduction.
Dysfunction of the B lymphocyte is considered to be involved in the pathogenesis of lupus nephritis (LN).
Intrarenal B cells have been found in several forms of inflammatory kidney disease.
B-cell activating factor (BAFF) regulates B lymphocyte proliferation and survival, and contributes to human autoimmune disease.
Their role in renal inflammation is not well defined.
Methods.
Clinical parameters and renal biopsies from 62 LN patients were prospectively analyzed.
We performed standard immunohistochemistry on serial paraffin tissue sections using monoclonal antibodies to CD20 and BAFF to investigate the characteristics and significance of locally infiltrating B cells and local BAFF expression in patients with LN.
Results.
Intrarenal B cells and/or BAFF were mainly distributed in the renal interstitium.
Compared to the LN-non-B-cell/BAFF expression group, proteinuria (g/24 hour), blood urea nitrogen, serum creatinine levels, LN renal activity, and chronicity indices, were all significantly greater in the LN-B-cell/BAFF expression groups.
The expression of BAFF was strongly associated with the quantity of B-cell infiltrate in the interstitium.
Conclusion.
As BAFF expression was strongly associated with B-cell infiltration, we hypothesize that altered B-cell differentiation and tolerance induced by excess BAFF may be central to the pathogenesis of LN.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Chuan-Yin& Shen, Yan& Chen, Xiao-Wei& Yan, Yu-Cheng& Wu, Feng-Xia& Dai, Ming…[et al.]. 2013. The Characteristics and Significance of Locally Infiltrating B Cells in Lupus Nephritis and Their Association with Local BAFF Expression. International Journal of Rheumatology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-511149
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Chuan-Yin…[et al.]. The Characteristics and Significance of Locally Infiltrating B Cells in Lupus Nephritis and Their Association with Local BAFF Expression. International Journal of Rheumatology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-511149
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Chuan-Yin& Shen, Yan& Chen, Xiao-Wei& Yan, Yu-Cheng& Wu, Feng-Xia& Dai, Ming…[et al.]. The Characteristics and Significance of Locally Infiltrating B Cells in Lupus Nephritis and Their Association with Local BAFF Expression. International Journal of Rheumatology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-511149
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-511149
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر