Circulating levels of soluble scavenger receptors (scd5& scd6)‎ in primary and secondary sjogren syndrome patients

الملخص EN

Objectives : to determine the existence of circulating levels of soluble scavenger receptors (sCD5& sCD6) in Jorgen's syndrome patients, either 1ry or 2ry to rheumatoid arthritis (RA) and/or systemic lupus erythematous (SLE).

Also, to analyze the correlation with clinical and immunological features of Jorgen's syndrome.

Methodology : Twelve consecutive RA patients, seven SLE patients and nine primary Jorgen's syndrome patients were studied.

We used a specific enzyme-linked immunosorbent assay (ELISA) to determine sCD5 and sCD6 levels.

Immunological tests included antinuclear antibodies (ANA) tested with (indirect immunofluorescence using HEP-2 as the substrate), rheumatoid factor (RF) quantitative (Integra-400-Roche Diagnostics) and complement factors (C3 and C4) (Integra-400- Roche Diagnostics).

We also estimated precipitating antibodies to extractable nuclear antigens Ro / SS-A and La / SS-B autoantibodies with ELISA (Shield Diagnostics).

Results : detectable levels of sCD5 were found in: 4 (25.7 %) RA patients with mean ± standard error values of 9.4 ± 4.3 ng / mL; 2 SLE patients (18.2 %) with mean ±standard error values of 8.2 ± 4.1ng / mL and 4 (41 %) primary Jorgen's syndrome patients with mean ± standard error values of 3.56 ± 2.9ng / mL.

Detectable levels of sCD6 were found in 3 (24.3 %) RA patients with mean ± standard error values of 39.6 ± 9.61ng / mL ; 1 SLE patient (14.3 %) with mean ± standard error values of 33.7±8.3 ng / mL and 6 (70 %) primary Jorgen's syndrome patients with mean± standard error values of 26.3 ± 7.9ng / mL On the other hand, when the CD5 & CD6 levels were compared according to the presence or absence of immunological features (i.e.

hypo-complementemia) patients showed higher levels of circulating soluble scavenger receptors (sCD5 & sCD6) (p < 0.05 & p < 0.01) respectively than those without immunological features.

Conclusions : Patients involved in this study showed higher levels of circulating sCD5 and sCD6 when compared with controls.

Moreover, the existence of some immunological features (i.e.

hypo-complementemia) was associated with high levels of both soluble scavenger receptors.