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Long-Term Regeneration and Functional Recovery of a 15 mm Critical Nerve Gap Bridged by Tremella fuciformis Polysaccharide-Immobilized Polylactide Conduits
المؤلفون المشاركون
Yang, Shu-Hui
Jiang, Ching-Fen
Weng, Chih-tsung
Chan, Shan-Ho
Hsu, Shan-hui
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-21
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Novel peripheral nerve conduits containing the negatively charged Tremella fuciformis polysaccharide (TF) were prepared, and their efficacy in bridging a critical nerve gap was evaluated.
The conduits were made of poly(D,L-lactide) (PLA) with asymmetric microporous structure.
TF was immobilized on the lumen surface of the nerve conduits after open air plasma activation.
The TF-modified surface was characterized by the attenuated total reflection Fourier-transformed infrared spectroscopy and the scanning electron microscopy.
TF modification was found to enhance the neurotrophic gene expression of C6 glioma cells in vitro.
TF-modified PLA nerve conduits were tested for their ability to bridge a 15 mm gap of rat sciatic nerve.
Nerve regeneration was monitored by the magnetic resonance imaging.
Results showed that TF immobilization promoted the nerve connection in 6 weeks.
The functional recovery in animals receiving TF-immobilized conduits was greater than in those receiving the bare conduits during an 8-month period.
The degree of functional recovery reached ~90% after 8 months in the group of TF-immobilized conduits.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hsu, Shan-hui& Chan, Shan-Ho& Weng, Chih-tsung& Yang, Shu-Hui& Jiang, Ching-Fen. 2013. Long-Term Regeneration and Functional Recovery of a 15 mm Critical Nerve Gap Bridged by Tremella fuciformis Polysaccharide-Immobilized Polylactide Conduits. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-511508
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hsu, Shan-hui…[et al.]. Long-Term Regeneration and Functional Recovery of a 15 mm Critical Nerve Gap Bridged by Tremella fuciformis Polysaccharide-Immobilized Polylactide Conduits. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-511508
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hsu, Shan-hui& Chan, Shan-Ho& Weng, Chih-tsung& Yang, Shu-Hui& Jiang, Ching-Fen. Long-Term Regeneration and Functional Recovery of a 15 mm Critical Nerve Gap Bridged by Tremella fuciformis Polysaccharide-Immobilized Polylactide Conduits. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-511508
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-511508
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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