Prevalence of HIV-Associated Metabolic Abnormalities among Patients Taking First-Line Antiretroviral Therapy in Uganda
المؤلفون المشاركون
Mayanja-Kizza, Harriet
Manabe, Yukari C.
Opio, Kenneth
Sempa, Joseph
Otim, Marcel
Colebunders, Robert
Castelnuovo, Barbara
Omech, Bernard
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-23
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
While the introduction of highly active antiretroviral therapy decreased HIV-related morbidity and mortality rates in the sub-Saharan Africa, a subsequent increase in metabolic abnormalities has been observed.
We sought to determine the prevalence of HIV-associated metabolic abnormalities among patients on first-line antiretroviral therapy (ART) in an ART clinic in Kampala, Uganda.
Methods.
Four hundred forty-two consecutive patients on first-line ART for at least 12 months were screened for eligibility in a cross-sectional study, and 423 were enrolled.
Pre-ART patient characteristics were abstracted from medical charts, examinations included anthropometric measurement and physical assessment for lipodystrophy.
Results.
The prevalence of hyperglycemia and dyslipidemia was 16.3% (69/423) and 81.5% (345/423), respectively.
Prevalence of dyslipidemia between stavudine- and zidovudine-based regimens (91% versus 72%; P<0.001).
Being on stavudine (aOR 4.79, 95%, 2.45–9.38) and peak body weight (aOR 1.44, 95% CI 1.05–1.97) were independent risk factors for dylipidemia.
Stavudine (aOR 0.50, 95% CI 0.27–0.93) use was associated with lower risk for hyperglycemia while, and older age (aOR 1.31, 95% CI 1.11–1.56) and having a family history of DM (aOR 2.18, 95% CI 1.10–4.34) were independent risk factors for hyperglycemia.
Conclusions.
HIV-associated metabolic complications were prevalent among patients on thymidine analogue-containing ART regimens.
Screening for lipid and glucose abnormalities should be considered in ART patients because of cardiovascular risks.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Omech, Bernard& Sempa, Joseph& Castelnuovo, Barbara& Opio, Kenneth& Otim, Marcel& Mayanja-Kizza, Harriet…[et al.]. 2012. Prevalence of HIV-Associated Metabolic Abnormalities among Patients Taking First-Line Antiretroviral Therapy in Uganda. ISRN AIDS،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-511566
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Omech, Bernard…[et al.]. Prevalence of HIV-Associated Metabolic Abnormalities among Patients Taking First-Line Antiretroviral Therapy in Uganda. ISRN AIDS No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-511566
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Omech, Bernard& Sempa, Joseph& Castelnuovo, Barbara& Opio, Kenneth& Otim, Marcel& Mayanja-Kizza, Harriet…[et al.]. Prevalence of HIV-Associated Metabolic Abnormalities among Patients Taking First-Line Antiretroviral Therapy in Uganda. ISRN AIDS. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-511566
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-511566
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر