Immunological Characteristics of Hyperreactive Malarial Splenomegaly Syndrome in Sudanese Patients
المؤلفون المشاركون
Alkadarou, Abedelgader
Alkadarou, Tayseer
Elhassan, Ibrahim M.
Troye-Blomberg, Marita
El Hassan, Ahmed Mohamed
Musa, Ahmed Mudawi
Mahfuz, Muhammad Salih
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-05
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Hyperreactive Malarial Splenomegaly (HMS) is defined as a massive enlargement of the spleen resulting from abnormal immune responses after repeated exposure to the malaria parasites.
This study was carried out in Khartoum, Sudan.
Sudan is considered to be one of the countries where HMS is quite prevalent.
The objective of the study was to determine the incidence of HMS in patients who reported to the Omdurman Tropical Diseases Hospital (OMTDH) in Sudan and to investigate the basic laboratory and immunological characteristics of this condition in these patients.
A cross-sectional study was carried out in OMTDH, and all patients with enlarged spleens were included in the study.
Thirty-one out of 335 (9.3%) patients were diagnosed as having the HMS condition using international criteria for HMS diagnosis.
The mean serum immunoglobulin M (IgM) levels in HMS patient groups were 14.3±5 g/L, and this was significantly higher compared with geographically matched controls (P<0.001).
Immunoglobulin G (IgG) C anticircumsporozoite (CSP) antibody levels were higher in the HMS patients although the difference was not statistically significant, when compared with a group of patients with mild malaria.
In comparison with naïve European controls, both the HMS and the mild malaria groups had significantly higher antimalarial antibody levels P<0.001 and P<0.01, respectively.
Plasma levels of interleukin 10 (IL10) and interferon gamma (IFNγ) were significantly increased in the HMS patients compared with the healthy control donors (P<0.05 and P<0.01) for IL10 and IFNγ, respectively.
The findings of this study suggest that HMS is one of the significant causes of tropical splenomegaly in Sudan.
HMS is associated with significant elevations of circulating IgM and antimalarial IgG antibodies as well as IL10 and IFNγ.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alkadarou, Tayseer& Musa, Ahmed Mudawi& Alkadarou, Abedelgader& Mahfuz, Muhammad Salih& Troye-Blomberg, Marita& El Hassan, Ahmed Mohamed…[et al.]. 2013. Immunological Characteristics of Hyperreactive Malarial Splenomegaly Syndrome in Sudanese Patients. Journal of Tropical Medicine،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-511647
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alkadarou, Tayseer…[et al.]. Immunological Characteristics of Hyperreactive Malarial Splenomegaly Syndrome in Sudanese Patients. Journal of Tropical Medicine No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-511647
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alkadarou, Tayseer& Musa, Ahmed Mudawi& Alkadarou, Abedelgader& Mahfuz, Muhammad Salih& Troye-Blomberg, Marita& El Hassan, Ahmed Mohamed…[et al.]. Immunological Characteristics of Hyperreactive Malarial Splenomegaly Syndrome in Sudanese Patients. Journal of Tropical Medicine. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-511647
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-511647
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر