Influence of Age and Neurotoxic HAART Use on Frequency of HIV Sensory Neuropathy
المؤلفون المشاركون
Oshinaike, O. Olajumoke
Ogbera, Anthonia
Ojini, I. Frank
Danesi, A. Mustapha
Ojo, O. Oluwadamilola
Okubadejo, U. Njideka
Akinbami, A. Akinsegun
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-17
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Sensory neuropathy (SN) is one of the most common AIDS-associated neurologic disorders especially in the era of highly active antiretroviral therapy (HAART).
The aim of this study was to determine the prevalence of SN among highly-active-antiretroviral-therapy- (HAART-) experienced and HAART-naïve HIV-positive individuals and to investigate the relationship to demographic, clinical, and laboratory factors.
Methods.
323 patients with HIV infection (142 on HAART and 181 HAART naïve) were enrolled in a cross-sectional neuropathy screening program.
Data was collected using structured questionnaires which contained the brief peripheral neuropathy screening tool of AIDS Clinical Trial Group protocol.
Neuropathy was defined by the presence of at least 1 clinical sign in a distal, symmetrical pattern.
Patients were classified as symptomatic if they described aching, stabbing, or burning pain, paresthesia, or numbness in a similar distribution.
Demographic, clinical, and laboratory details were documented as risk factors.
Result.
The prevalence of sensory neuropathy was 39.0% (126/323), (of which 29/126 (23%)) were symptomatic.
Amongst those on HAART, 60/142 (42.3%) had SN compared to 66/181 (36.5%) HAART-naïve individuals (P=0.29).
On multivariate analyses, the independent associations with SN were increasing age (P=0.03) and current exposure to stavudine (P=0.00).
Gender (P=0.99) height (P=0.07) use of HAART (P=0.50), duration of HAART treatment (P=0.10), and lower CD4 count (P=0.12) were not associated with an increased SN risk.
Conclusion.
HIV SN remains common despite improved immunologic function associated with HAART and decreased neurotoxic HAART use.
In this cross-sectional analysis, age and stavudine-based therapies were the independent risk factors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oshinaike, O. Olajumoke& Akinbami, A. Akinsegun& Ojo, O. Oluwadamilola& Ogbera, Anthonia& Okubadejo, U. Njideka& Ojini, I. Frank…[et al.]. 2012. Influence of Age and Neurotoxic HAART Use on Frequency of HIV Sensory Neuropathy. AIDS Research and Treatment،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-511689
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oshinaike, O. Olajumoke…[et al.]. Influence of Age and Neurotoxic HAART Use on Frequency of HIV Sensory Neuropathy. AIDS Research and Treatment No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-511689
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oshinaike, O. Olajumoke& Akinbami, A. Akinsegun& Ojo, O. Oluwadamilola& Ogbera, Anthonia& Okubadejo, U. Njideka& Ojini, I. Frank…[et al.]. Influence of Age and Neurotoxic HAART Use on Frequency of HIV Sensory Neuropathy. AIDS Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-511689
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-511689
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر