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Efficacy and Safety of a Chinese Herbal Formula (Invigorating Kidney and Strengthening Spleen) in Chronic Hepatitis B Virus Carrier : Results from a Multicenter, Randomized, Double-Blind, and Placebo-Controlled Trial
المؤلفون المشاركون
Zhan, Bolin
Liu, Xinliang
Qiu, Mei
Zhou, Xiaozhou
Xiong, Yiqun
Xing, Yufeng
Zheng, Yingjun
Tong, Guangdong
He, Jinsong
Gao, Hui
Zhou, Daqiao
Peng, Lisheng
Zhang, Xiaohui
Chen, Yingjie
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-10
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
A Chinese Herbal Formula (CHF) has acquired a certain therapeutic effect on chronic HBV infection.
To assess the efficacy and safety of CHF on HBV replication in chronic HBV carriers, we performed a randomized, double-blind, and placebo-controlled trial involving patients from 16 centers.
A total of 300 confirmed chronic HBV carriers were randomized at baseline in a ratio of 2 : 1 to receive either CHF or placebo for 52 weeks.
The results showed that a greater proportion of CHF than placebo treated patients achieved virological response at week 52; the mean decline of serum HBsAg levels in the CHF group dropped more obviously than that in the control group at all stages of the treatment; however, the rates of HBeAg loss and seroconversion had no difference between the two groups.
Meanwhile, were presented significant increases in IFN-γ; IL-2 levels and reductions in IL-4 and IL-10 levels in the treatment group compared to the control group at week 52.
There were no drug-related serious adverse events.
In conclusion, the treatment with 52-week CHF is safe and effective in inhibiting HBV replication in chronic HBV carriers.
The ability of the compound to modulate host immune function probably contributed to this effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
He, Jinsong& Zhou, Daqiao& Tong, Guangdong& Xing, Yufeng& Chen, Yingjie& Zhang, Xiaohui…[et al.]. 2013. Efficacy and Safety of a Chinese Herbal Formula (Invigorating Kidney and Strengthening Spleen) in Chronic Hepatitis B Virus Carrier : Results from a Multicenter, Randomized, Double-Blind, and Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-511730
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
He, Jinsong…[et al.]. Efficacy and Safety of a Chinese Herbal Formula (Invigorating Kidney and Strengthening Spleen) in Chronic Hepatitis B Virus Carrier : Results from a Multicenter, Randomized, Double-Blind, and Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-511730
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
He, Jinsong& Zhou, Daqiao& Tong, Guangdong& Xing, Yufeng& Chen, Yingjie& Zhang, Xiaohui…[et al.]. Efficacy and Safety of a Chinese Herbal Formula (Invigorating Kidney and Strengthening Spleen) in Chronic Hepatitis B Virus Carrier : Results from a Multicenter, Randomized, Double-Blind, and Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-511730
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-511730
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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