Lipid-Lowering and Antioxidative Activities of Aqueous Extracts of Ocimum sanctum L. Leaves in Rats Fed with a High-Cholesterol Diet
المؤلفون المشاركون
Poungshompoo, Somlak
Thirawarapan, Suwan
Devakul Na Ayutthaya, Watcharaporn
Songsak, Thanapat
Suanarunsawat, Thamolwan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-09-21
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
The present study was conducted to investigate the lipid-lowering and antioxidative activities of Ocimum sanctum L.
(OS) leaf extracts in liver and heart of rats fed with high-cholesterol (HC) diet for seven weeks.
The results shows that OS suppressed the high levels of serum lipid profile and hepatic lipid content without significant effects on fecal lipid excretion.
Fecal bile acids excretion was increased in HC rats treated with OS.
The high serum levels of TBARS as well as AST, ALT, AP, LDH, CK-MB significantly decreased in HC rats treated with OS.
OS suppressed the high level of TABARS and raised the low activities of GPx and CAT without any impact on SOD in the liver.
As for the cardiac tissues, OS lowered the high level of TABARS, and raised the activities of GPx, CAT, and SOD.
Histopathological results show that OS preserved the liver and myocardial tissues.
It can be concluded that OS leaf extracts decreased hepatic and serum lipid profile, and provided the liver and cardiac tissues with protection from hypercholesterolemia.
The lipid-lowering effect is probably due to the rise of bile acids synthesis using cholesterol as precursor, and antioxidative activity to protect liver from hypercholesterolemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Suanarunsawat, Thamolwan& Devakul Na Ayutthaya, Watcharaporn& Songsak, Thanapat& Thirawarapan, Suwan& Poungshompoo, Somlak. 2011. Lipid-Lowering and Antioxidative Activities of Aqueous Extracts of Ocimum sanctum L. Leaves in Rats Fed with a High-Cholesterol Diet. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-511739
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Suanarunsawat, Thamolwan…[et al.]. Lipid-Lowering and Antioxidative Activities of Aqueous Extracts of Ocimum sanctum L. Leaves in Rats Fed with a High-Cholesterol Diet. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-511739
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Suanarunsawat, Thamolwan& Devakul Na Ayutthaya, Watcharaporn& Songsak, Thanapat& Thirawarapan, Suwan& Poungshompoo, Somlak. Lipid-Lowering and Antioxidative Activities of Aqueous Extracts of Ocimum sanctum L. Leaves in Rats Fed with a High-Cholesterol Diet. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-511739
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-511739
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر