Prevalence of Anti-Neu5Gc Antibodies in Patients with Hypothyroidism
المؤلفون المشاركون
Mazmanidi, Alexandra
Kynigopoulos, Stavros
Eleftheriou, Phaedra
Skepastianos, Petros
Papara, Dafni
Giovou, Alexandra
Efterpiou, Maria
Petrou, Christos
Vagdatli, Eleni
Yovos, John
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
N-Glycolylneuraminic acid (Neu5Gc) is a sialic acid synthesized by animals, but not by humans or birds.
However, it can be incorporated in human cells and can trigger immune response.
In the present study, we detected anti-Neu5Gc antibodies in samples of the general population and of patients suffering from hypothyroidism/Hashimoto’s disease, which is known to have autoimmune origin.
Methods.
Antibodies were measured using enzyme-immunosorbent techniques.
Results.
Serum anti-Neu5Gc IgG antibodies were higher in patients with hypothyroidism (mean: 14.8±15.9 μg/mL, median: 10.0 μg/mL, P=0.0003, Mann-Whitney) and even higher in the group with Hashimoto’s thyroiditis (mean: 31.1±16.3 μg/mL, median: 27.2 μg/mL, P=0.0000, Mann-Whitney) compared to the general population (mean: 5.3±4.7 μg/mL, median : 4 μg/mL).
All anti-TPO positive samples had anti-Neu5Gc antibody concentration higher than the mean value of the general population while anti-TPO concentration was increased as anti-Neu5Gc concentration increased.
Low concentrations of IgA and IgM antibodies were measured in both general population and patient groups.
Conclusion.
The increased values of anti-Neu5Gc antibodies in patients with hypothyroidism/Hashimoto’s disease and the correlation of anti-TPO incidence with increased anti-Neu5Gc concentration raise the possibility of an association between anti-Neu5Gc antibody development and autoimmune hypothyroidism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Eleftheriou, Phaedra& Kynigopoulos, Stavros& Giovou, Alexandra& Mazmanidi, Alexandra& Yovos, John& Skepastianos, Petros…[et al.]. 2014. Prevalence of Anti-Neu5Gc Antibodies in Patients with Hypothyroidism. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-511847
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Eleftheriou, Phaedra…[et al.]. Prevalence of Anti-Neu5Gc Antibodies in Patients with Hypothyroidism. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-511847
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Eleftheriou, Phaedra& Kynigopoulos, Stavros& Giovou, Alexandra& Mazmanidi, Alexandra& Yovos, John& Skepastianos, Petros…[et al.]. Prevalence of Anti-Neu5Gc Antibodies in Patients with Hypothyroidism. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-511847
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-511847
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر