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New Aspects in Immunopathology of Mycobacterium tuberculosis
المؤلفون المشاركون
Varahram, M.
Mortaz, E.
Farnia, P.
Masjedi, MR
Bahadori, M.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-28
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Our understanding of tuberculosis (TB) pathology and immunology has become extensively deeper and more refined since the identification of Mycobacterium tuberculosis (MTB) as the etiologic agent of disease by Dr.
Robert Koch in 1882.
A great challenge in chronic disease is to understand the complexities, mechanisms, and consequences of host interactions with pathogens.
TB, caused by MTB, is a major health problem in world, with 10 million new cases diagnosed each year.
Innate immunity is shown playing an important role in the host defense against the MTB, and the first step in this process is recognition of MTB by cells of the innate immune system.
Several classes of pattern recognition receptors (PPRs) are involved in the recognition of MTB, including toll-like receptors (TLRs), C-type lectin receptors (CLRs), and nod-like receptors (NLRs).
Among the TLR family, TLR1, TLR2, TLR4, and TLR9 and their down streams, proteins play the most prominent roles in the initiation of the immune response against MTB.
Beside of TLRs signaling, recently the activation of inflammasome pathway in the pathogenesis of TB much appreciated.
Knowledge about these signaling pathways is crucial for understanding the pathophysiology of TB, on one hand, and for the development of novel strategies of vaccination and treatment such as immunotherapy on the other.
Given the critical role of TLRs/inflammasome signaling in innate immunity and initiation of the appropriate adaptive response, the regulation of these pathways is likely to be an important determinant of the clinical outcome of MTB infection.
In this review paper we focused on the immune response, which is the recognition of MTB by inflammatory innate immune cells following infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mortaz, E.& Varahram, M.& Farnia, P.& Bahadori, M.& Masjedi, MR. 2012. New Aspects in Immunopathology of Mycobacterium tuberculosis. ISRN Immunology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-511897
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mortaz, E.…[et al.]. New Aspects in Immunopathology of Mycobacterium tuberculosis. ISRN Immunology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-511897
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mortaz, E.& Varahram, M.& Farnia, P.& Bahadori, M.& Masjedi, MR. New Aspects in Immunopathology of Mycobacterium tuberculosis. ISRN Immunology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-511897
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-511897
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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