Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways
المؤلفون المشاركون
Zhang, Wen
Zhang, Hong
Zhou, Fan
Wang, Li Hui
Sha, Sha
Wu, Chun Fu
Yang, Jing Yu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-07-02
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Seed oil of Brucea javanica (BJO) is extracted from the seeds of herb medicine Brucea javanica (L.), and its emulsion formulation (BJOE) has been used clinically to treat carcinomas for many years in China.
The antileukemia potential of BJO was investigated in human acute myeloid leukemia cell lines (AML) U937 and HL-60 in vitro and in a mouse U937 xenograft tumor model.
BJO induced AML cell apoptosis through activation of caspase-8 and modulation of apoptosis-related proteins.
Meanwhile, the inhibition of survivin and XIAP increased the cytotoxicity of BJO.
Consistent with these findings, BJO also increased subG1 phase cells and cause PARP cleavage in AML patients' leukemia cells.
In contrast, only weak cytotoxicity of BJO was found in peripheral blood lymphocytes (PBLs) of healthy volunteers.
Moreover, oleic acid and linoleic acid were found to be the active components of BJO.
Our study provided strong evidence for the first time that BJO induced apoptosis of both cultured and primary AML cells.
Furthermore, intravenous injection of BJO significantly inhibited U937 tumor growth in the xenograft mouse model.
These results suggest that BJO may have a therapeutic role in the treatment of human leukemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Hong& Yang, Jing Yu& Zhou, Fan& Wang, Li Hui& Zhang, Wen& Sha, Sha…[et al.]. 2011. Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-511999
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Hong…[et al.]. Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-511999
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Hong& Yang, Jing Yu& Zhou, Fan& Wang, Li Hui& Zhang, Wen& Sha, Sha…[et al.]. Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-511999
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-511999
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر