Genetic Predisposition for Dermal Problems in Hexavalent Chromium Exposed Population
المؤلفون المشاركون
Goel, Sudhir K.
Agarwal, Sudhir K.
Bihari, Vipin
Sharma, Priti
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
We studied the effect of genetic susceptibility on hexavalent chromium induced dermal adversities.
The health status of population was examined from the areas of Kanpur (India) having the elevated hexavalent chromium levels in groundwater.
Blood samples were collected for DNA isolation to conduct polymorphic determination of genes, namely: NQO1 (C609T), hOGG1 (C1245G), GSTT1, and GSTM1 (deletion).
Symptomatic exposed subjects (n=38) were compared with asymptomatic exposed subjects (n=108) along with asymptomatic controls (n=148) from a non contaminated reference community.
Exposed symptomatic group consisted of 36.8% subjects who were GSTM1 null genotyped as compared to asymptomatic where only 19.4% subjects were null.
The exposed subjects with GSTM1 null genotype were more susceptible to dermal adversities in comparison with wild genotyped subjects (OR = 2.42; 95% CI = 1.071–5.451).
Age, smoking, gender or duration of residence were not found to have any confounding effect towards this association.
Association with other genes was not statistically significant, nonetheless, possible contribution by these genes cannot be ruled out.
In conclusion, variation in the polymorphic status of GSTM1 gene may influence dermal outcomes among residents from Cr(VI) contaminated areas.
Further studies are therefore, needed to examine these observations among different population groups.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sharma, Priti& Bihari, Vipin& Agarwal, Sudhir K.& Goel, Sudhir K.. 2012. Genetic Predisposition for Dermal Problems in Hexavalent Chromium Exposed Population. Journal of Nucleic Acids،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-512222
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sharma, Priti…[et al.]. Genetic Predisposition for Dermal Problems in Hexavalent Chromium Exposed Population. Journal of Nucleic Acids No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-512222
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sharma, Priti& Bihari, Vipin& Agarwal, Sudhir K.& Goel, Sudhir K.. Genetic Predisposition for Dermal Problems in Hexavalent Chromium Exposed Population. Journal of Nucleic Acids. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-512222
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512222
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر