Benfotiamine Counteracts Smoking-Induced Vascular Dysfunction in Healthy Smokers
المصدر
International Journal of Vascular Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Smoking induces endothelial dysfunction (ED) mainly by exacerbating oxidative stress (OS) and inflammation.
Benfotiamine, a thiamine prodrug with high bioavailability, prevents nicotine-induced vascular dysfunction in rats.
It remained unknown whether this effect also occurs in humans.
Methods.
Therefore, 20 healthy volunteers (mean age: 38 years) were investigated twice, 7–10 days apart in a randomized, cross-over, and investigator-blinded design.
Vascular function was assessed by flow-mediated vasodilatation (FMD) of the brachial artery and by measurements of the soluble vascular cell adhesion molecule (sVCAM)-1.
Investigations were performed after an overnight fast as well as 20 minutes after one cigarette smoking.
On another day, the same procedure was applied following a 3-day oral therapy with benfotiamine (1050 mg/day).
Ten patients were randomized to start with smoking alone, and ten started with benfotiamine.
Results.
Results are expressed as (mean ± SEM).
Smoking acutely induced a decrease in FMD by 50% (∗∗P<0.001 versus baseline) an effect significantly reduced by benfotiamine treatment to 25%∗§ (∗P<0.05 versus baseline, §P<0.05 versus smoking alone).
Smoking-induced elevation in sVCAM-1 was also prevented by benfotiamine.
The endothelium-independent vasodilatation remained unaltered between days.
Conclusion.
In healthy volunteers, smoking blunts vascular function mirrored by a decrease in FMD and an increase in sVCAM-1.
Short-term treatment with benfotiamine significantly reduces these effects, showing protective vascular properties.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
2012. Benfotiamine Counteracts Smoking-Induced Vascular Dysfunction in Healthy Smokers. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-512236
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Benfotiamine Counteracts Smoking-Induced Vascular Dysfunction in Healthy Smokers. International Journal of Vascular Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-512236
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Benfotiamine Counteracts Smoking-Induced Vascular Dysfunction in Healthy Smokers. International Journal of Vascular Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-512236
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512236
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر