Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation

المؤلفون المشاركون

Safaralizadeh, Reza
Kazemzadeh-Bavili, Mina
Valinezhad Orang, Ayla

المصدر

International Journal of Genomics

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-15، 15ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-08-10

دولة النشر

مصر

عدد الصفحات

15

التخصصات الرئيسية

العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء

الملخص EN

Discovered in 1993, micoRNAs (miRNAs) are now recognized as one of the major regulatory gene families in eukaryotes.

To date, 24521 microRNAs have been discovered and there are certainly more to come.

It was primarily acknowledged that miRNAs result in gene expression repression at both the level of mRNA stability by conducting mRNA degradation and the level of translation (at initiation and after initiation) by inhibiting protein translation or degrading the polypeptides through binding complementarily to 3′UTR of the target mRNAs.

Nevertheless, some studies revealed that miRNAs have the capability of activating gene expression directly or indirectly in respond to different cell types and conditions and in the presence of distinct cofactors.

This reversibility in their posttranslational gene regulatory natures enables the bearing cells to rapidly response to different cell conditions and consequently block unnecessary energy wastage or maintain the cell state.

This paper provides an overview of the current understandings of the miRNA characteristics including their genes and biogenesis, as well as their mediated downregulation.

We also review up-to-date knowledge of miRNA-mediated gene upregulation through highlighting some notable examples and discuss the emerging concepts of their associations with other posttranscriptional gene regulation processes.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Valinezhad Orang, Ayla& Safaralizadeh, Reza& Kazemzadeh-Bavili, Mina. 2014. Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation. International Journal of Genomics،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-512369

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Valinezhad Orang, Ayla…[et al.]. Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation. International Journal of Genomics No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-512369

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Valinezhad Orang, Ayla& Safaralizadeh, Reza& Kazemzadeh-Bavili, Mina. Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation. International Journal of Genomics. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-512369

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-512369