Impact of Undetected Comorbidity on Treatment and Outcomes of Breast Cancer
المؤلفون المشاركون
Danese, Mark D.
Gleeson, Michelle L.
Valderas, José M.
Griffiths, Robert I.
المصدر
International Journal of Breast Cancer
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-13
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Preexisting comorbidity adversely impacts breast cancer treatment and outcomes.
We examined the incremental impact of comorbidity undetected until cancer.
We followed breast cancer patients in SEER-Medicare from 12 months before to 84 months after diagnosis.
Two comorbidity indices were constructed: the National Cancer Institute index, using 12 months of claims before cancer, and a second index for previously undetected conditions, using three months after cancer.
Conditions present in the first were excluded from the second.
Overall, 6,184 (10.1%) had ≥1 undetected comorbidity.
Chronic obstructive pulmonary disease (38%) was the most common undetected condition.
In multivariable analyses that adjusted for comorbidity detected before cancer, older age, later stage, higher grade, and poor performance status all were associated with higher odds of ≥1 undetected comorbidity.
In stage I–III cancer, undetected comorbidity was associated with lower adjusted odds of receiving adjuvant chemotherapy (Odds Ratio (OR) = 0.81, 95% Confidence Interval (CI) 0.73–0.90, P<0.0001; OR=0.38, 95% CI 0.30–0.49, P<0.0001; index score 1 or ≥2, respectively), and with increased mortality (Hazard Ratio (HR) = 1.45, 95% CI 1.38–1.53, P<0.0001; HR=2.38, 95% CI 2.18–2.60, P<0.0001; index score 1 or ≥2).
Undetected comorbidity is associated with less aggressive treatment and higher mortality in breast cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Griffiths, Robert I.& Gleeson, Michelle L.& Valderas, José M.& Danese, Mark D.. 2014. Impact of Undetected Comorbidity on Treatment and Outcomes of Breast Cancer. International Journal of Breast Cancer،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-512389
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Griffiths, Robert I.…[et al.]. Impact of Undetected Comorbidity on Treatment and Outcomes of Breast Cancer. International Journal of Breast Cancer No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-512389
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Griffiths, Robert I.& Gleeson, Michelle L.& Valderas, José M.& Danese, Mark D.. Impact of Undetected Comorbidity on Treatment and Outcomes of Breast Cancer. International Journal of Breast Cancer. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-512389
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512389
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر