Neuroprotective Effects of Centella asiatica against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress
المؤلفون المشاركون
Dogra, Samrita
Prakash, Atish
Kumar, Anil
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-09-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Oxidative stress appears to be an early event involved in the pathogenesis of Alzheimer's disease.
The present study was designed to investigate the neuroprotective effects of Centella asiatica against colchicine-induced memory impairment and oxidative damage in rats.
Colchicine (15 μg/5 μL) was administered intracerebroventricularly in the lateral ventricle of male wistar rats.
Morris water maze and plus-maze performance tests were used to assess memory performance tasks.
Various biochemical parameters such as lipid peroxidation, nitrite, reduced glutathione, glutathione-S-transferase, superoxide dismutase, acetylcholinesterase were also assessed.
ICV colchicine resulted marked memory impairment and oxidative damage.
Chronic treatment with Centella asiatica extract (150 and 300 mg/kg, p.o.) for a period of 25 days, beginning 4 days prior to colchicine administration, significantly attenuated colchicine-induced memory impairment and oxidative damage.
Besides, Centella asiatica significantly reversed colchicines administered increase in acetylcholinesterase activity.
Thus, present study indicates protective effect of Centella asiatica against colchicine-induced cognitive impairment and associated oxidative damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kumar, Anil& Dogra, Samrita& Prakash, Atish. 2009. Neuroprotective Effects of Centella asiatica against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress. International Journal of Alzheimer's Disease،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-512526
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kumar, Anil…[et al.]. Neuroprotective Effects of Centella asiatica against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress. International Journal of Alzheimer's Disease No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-512526
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kumar, Anil& Dogra, Samrita& Prakash, Atish. Neuroprotective Effects of Centella asiatica against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress. International Journal of Alzheimer's Disease. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-512526
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512526
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر