Validation of Hepascore as a Predictor of Liver Fibrosis in Patients with Chronic Hepatitis C Infection
المؤلفون المشاركون
Hoseini, Hannan
Yaran, Majid
Kalantari, Hamid
Babak, Anahita
المصدر
Hepatitis Research and Treatment
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-12-28
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
Liver biopsy is an invasive determinator for hepatic fibrosis.
Serum biomarkers can probably be used as an alternative to liver biopsy in assessment of the degree of fibrosis in patients with chronic Hepatitis C.
Method.
Eighty patients with chronic Hepatitis C were included in the study using simple nonrandom sampeling metod.
After fulfillment of liver biopsy, the patients were categorized according to the METAVIR Scoring system.
The Hepascore algorithm is computed based on age, sex, and the serum levels of total bilirubin, δ-glutamyl transferase, α2-Macroglobulin, and hyaluronic acid.
The spearman and ROC tests were used.
Results.
According to the liver biopsy results, 12, 25, 20, 7 and 16 patients had F0, F1, F2, F3, and F4, respectively.
With regard to the 0.34 cut-off point Hepascore had 67%, 56%, 64%, and 56% sensitivity, specificity, respectively, positive prediction value (PPV), and negative prediction value (NPV), respectively, for diagnosis of significant fibrosis.
For a Hepascore cut-off point 0.61, sensitivity, specificity, respectively, PPV and NPB 82%, 86%, 70%, and 92% in diagnosis of severe fibrosis.
For a Hepascore cut-off point 0.84, sensitivity, specificity, PPV and NPB were respectively 100%, 97%, 89%, and 100% for diagnosis of cirrhosis.
Conclusion.
Hepascore has a high value in diagnosis of the level of fibrosis, particularly cirrhosis.
Therefore, it can be used for primary screening of patients to determine the need for liver biopsy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kalantari, Hamid& Hoseini, Hannan& Babak, Anahita& Yaran, Majid. 2011. Validation of Hepascore as a Predictor of Liver Fibrosis in Patients with Chronic Hepatitis C Infection. Hepatitis Research and Treatment،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-512592
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kalantari, Hamid…[et al.]. Validation of Hepascore as a Predictor of Liver Fibrosis in Patients with Chronic Hepatitis C Infection. Hepatitis Research and Treatment No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-512592
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kalantari, Hamid& Hoseini, Hannan& Babak, Anahita& Yaran, Majid. Validation of Hepascore as a Predictor of Liver Fibrosis in Patients with Chronic Hepatitis C Infection. Hepatitis Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-512592
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512592
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر