Hypertension Secondary to PHPT : Cause or Coincidence?

المؤلفون المشاركون

Schiffl, Helmut
Lang, Susanne M.

المصدر

International Journal of Endocrinology

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-03-07

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الأحياء

الملخص EN

Primary hyperparathyroidism (PHPT) may be associated with arterial hypertension.

The underlying mechanisms are not fully understood and reversibility by parathyroid surgery is controversial.

This study aimed to characterize pressor hormones, vascular reactivity to norepinephrine, and cytosolic-free calcium in platelets in 15 hypertensive patients with hypercalcaemic PHPT before and after successful parathyroidectomy and to compare them with 5 pre-hypertensive patients with normocalcaemic PHPT, 8 normotensive patients with hypercalcaemic PHPT and 15 normal controls.

Hypertensive patients with hypercalcaemic PHPT had slightly higher levels of pressor hormones (P<0.05), enhanced cardiovascular reactivity to norepinephrine (P<0.05) and increased cytosolic calcium in platelets (P<0.05) than controls.

Pre-hypertensive patients with normocalcaemic PHPT had intermediate values of increased cardiovascular reactivity and cytosolic calcium.

Normotensive patients with hypercalcaemic PHPT and normotensive controls had comparable pressor hormone concentrations and intracellular calcium levels.

Successful parathyroidectomy was associated with normal blood pressure values and normalisation of pressor hormone concentrations, cardiovascular pressor reactivity and cytosolic free calcium.

Our results suggest that parathyroid hypertension is mediated/maintained, at least in part, by functional alterations of vascular smooth muscle cells and can be cured by parathyroidectomy in those patients who do not have primary hypertension.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Schiffl, Helmut& Lang, Susanne M.. 2011. Hypertension Secondary to PHPT : Cause or Coincidence?. International Journal of Endocrinology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-512782

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Schiffl, Helmut& Lang, Susanne M.. Hypertension Secondary to PHPT : Cause or Coincidence?. International Journal of Endocrinology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-512782

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Schiffl, Helmut& Lang, Susanne M.. Hypertension Secondary to PHPT : Cause or Coincidence?. International Journal of Endocrinology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-512782

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-512782