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Cardiovascular Risk in Systemic Autoimmune Diseases : Epigenetic Mechanisms of Immune Regulatory Functions
المؤلفون المشاركون
Pérez-Sánchez, Carlos
Rodriguez-Ariza, Antonio
Ramos-Casals, Manuel
López-Pedrera, Chary
Santos-Gonzalez, Monica
Cuadrado, Maria José
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-09-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Autoimmune diseases (AIDs) have been associated with accelerated atherosclerosis (AT) leading to increased cardio- and cerebrovascular disease risk.
Traditional risk factors, as well as systemic inflammation mediators, including cytokines, chemokines, proteases, autoantibodies, adhesion receptors, and others, have been implicated in the development of these vascular pathologies.
Yet, the characteristics of vasculopathies may significantly differ depending on the underlying disease.
In recent years, many new genes and signalling pathways involved in autoimmunity with often overlapping patterns between different disease entities have been further detected.
Epigenetics, the control of gene packaging and expression independent of alterations in the DNA sequence, is providing new directions linking genetics and environmental factors.
Epigenetic regulatory mechanisms comprise DNA methylation, histone modifications, and microRNA activity, all of which act upon gene and protein expression levels.
Recent findings have contributed to our understanding of how epigenetic modifications could influence AID development, not only showing differences between AID patients and healthy controls, but also showing how one disease differs from another and even how the expression of key proteins involved in the development of each disease is regulated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
López-Pedrera, Chary& Pérez-Sánchez, Carlos& Ramos-Casals, Manuel& Santos-Gonzalez, Monica& Rodriguez-Ariza, Antonio& Cuadrado, Maria José. 2011. Cardiovascular Risk in Systemic Autoimmune Diseases : Epigenetic Mechanisms of Immune Regulatory Functions. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-512783
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
López-Pedrera, Chary…[et al.]. Cardiovascular Risk in Systemic Autoimmune Diseases : Epigenetic Mechanisms of Immune Regulatory Functions. Clinical and Developmental Immunology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-512783
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
López-Pedrera, Chary& Pérez-Sánchez, Carlos& Ramos-Casals, Manuel& Santos-Gonzalez, Monica& Rodriguez-Ariza, Antonio& Cuadrado, Maria José. Cardiovascular Risk in Systemic Autoimmune Diseases : Epigenetic Mechanisms of Immune Regulatory Functions. Clinical and Developmental Immunology. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-512783
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512783
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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