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The Spontaneously Diabetic Torii Rat : An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications
المؤلفون المشاركون
Masuyama, Taku
Kakehashi, Akihiro
Shinohara, Masami
Ohta, Takeshi
Yokoi, Norihide
Sasase, Tomohiko
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-26
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The Spontaneously Diabetic Torii (SDT) rat is an inbred strain of Sprague-Dawley rat and recently is established as a nonobese model of type 2 diabetes (T2D).
Male SDT rats show high plasma glucose levels (over 700 mg/dL) by 20 weeks.
Male SDT rats show pancreatic islet histopathology, including hemorrhage in pancreatic islets and inflammatory cell infiltration with fibroblasts.
Prior to the onset of diabetes, glucose intolerance with hypoinsulinemia is also observed.
As a result of chronic severe hyperglycemia, the SDT rats develop profound complications.
In eyes, retinopathy, cataract, and neovascular glaucoma are observed.
Proliferative retinopathy, especially, resulting from retinal neovascular vessels is a unique characteristic of this model.
In kidney, mesangial proliferation and nodular lesion are observed.
Both peripheral neuropathy such as decreased nerve conduction velocity and thermal hypoalgesia and autonomic neuropathy such as diabetic diarrhea and voiding dysfunction have been reported.
Osteoporosis is another complication characterized in SDT rat.
Decreased bone density and low-turnover bone lesions are observed.
Taking advantage of these features, SDT rat has been used for evaluating antidiabetic drugs and drugs/gene therapy for diabetic complications.
In conclusion, the SDT rat is potentially a useful T2D model for studies on pathogenesis and treatment of diabetic complications in humans.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sasase, Tomohiko& Ohta, Takeshi& Masuyama, Taku& Yokoi, Norihide& Kakehashi, Akihiro& Shinohara, Masami. 2013. The Spontaneously Diabetic Torii Rat : An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-512914
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sasase, Tomohiko…[et al.]. The Spontaneously Diabetic Torii Rat : An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications. Journal of Diabetes Research No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-512914
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sasase, Tomohiko& Ohta, Takeshi& Masuyama, Taku& Yokoi, Norihide& Kakehashi, Akihiro& Shinohara, Masami. The Spontaneously Diabetic Torii Rat : An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-512914
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512914
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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