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Dangguijakyak-San Protects against 1-Methyl-4-phenyl-1,2,3,6,-tetrahydropyridine-Induced Neuronal Damage via Anti-Inflammatory Action
المؤلفون المشاركون
Kim, Hyo Geun
Oh, Myung Sook
Hwang, Deok-Sang
Jang, Jun-Bock
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Dangguijakyak-san (DJS), a famous traditional Korean multiherbal medicine, has been used to treat gynecological and neuro-associated disease.
Recent studies demonstrated that DJS has multiple bioactivities including neuroprotection.
In the present study, we were to investigate the effect of DJS and its mechanism in an in vitro and in vivo model of Parkinson’s disease (PD).
In primary mesencephalic culture system, DJS attenuated the dopaminergic cell damage induced by 1-methyl-4-phenylpyridine toxicity, and it inhibited production of inflammatory factors such as tumor necrosis factor α (TNF-α), nitric oxide (NO), and activation of microglial cells.
Then, we confirmed the effect of DJS in a mouse PD model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
In the pole test, DJS at 50 mg/kg/day for 5 days showed increase of motor activity showing shortened time to turn and locomotor activity compared with the MPTP only treated mice.
In addition, DJS significantly protected nigrostriatal dopaminergic neuron from MPTP stress.
Moreover, DJS showed inhibition of gliosis in the substantia nigra pars compacta.
These results have therapeutic implications for DJS in the treatment of PD via anti-inflammatory effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hwang, Deok-Sang& Kim, Hyo Geun& Jang, Jun-Bock& Oh, Myung Sook. 2013. Dangguijakyak-San Protects against 1-Methyl-4-phenyl-1,2,3,6,-tetrahydropyridine-Induced Neuronal Damage via Anti-Inflammatory Action. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-512918
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hwang, Deok-Sang…[et al.]. Dangguijakyak-San Protects against 1-Methyl-4-phenyl-1,2,3,6,-tetrahydropyridine-Induced Neuronal Damage via Anti-Inflammatory Action. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-512918
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hwang, Deok-Sang& Kim, Hyo Geun& Jang, Jun-Bock& Oh, Myung Sook. Dangguijakyak-San Protects against 1-Methyl-4-phenyl-1,2,3,6,-tetrahydropyridine-Induced Neuronal Damage via Anti-Inflammatory Action. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-512918
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512918
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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