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The Effects of Piroxicam and Deracoxib on Canine Mammary Tumour Cell Line
المؤلفون المشاركون
Deniz, Günnur
Çınar, Suzan
Üstüner, Oya
Erten, Gaye
Üstün Alkan, Fulya
Bakırel, Tülay
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Cyclooxygenase (COX) inhibitors, already widely used for the treatment of pain and inflammation, are considered as promising compounds for the prevention and treatment of neoplasia.
The aim of our study was to determine the direct antiproliferative effects of nonsteroidal anti-inflammatory drugs (NSAIDs), piroxicam and deracoxib, at a variety of concentrations as both single and combined treatments on canine mammary carcinoma cell line CMT-U27 and to understand the mechanisms of cell death.
MTT assay was performed to determine cell viability, and flow cytometric analyses were performed to evaluate apoptosis and cell cycle alterations.
Significant decrease in cell viability was observed at high concentrations of piroxicam and deracoxib in both single and combined treatments after 72 h incubation.
Combined treatment produced a significantly greater inhibition than that caused by either agent alone.
Also apoptotic cell number was increased by both drugs at the cytotoxic concentrations.
However, concomitant treatment of cells with piroxicam and deracoxib resulted in significant induction of apoptosis at lower concentrations and accumulation of cells in the G0/G1 phase.
Significant cytotoxic effects exhibited by the combination of piroxicam and deracoxib against canine mammary carcinoma cells in vitro suggest an attractive approach for the treatment of canine mammary carcinoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Üstün Alkan, Fulya& Üstüner, Oya& Bakırel, Tülay& Çınar, Suzan& Erten, Gaye& Deniz, Günnur. 2012. The Effects of Piroxicam and Deracoxib on Canine Mammary Tumour Cell Line. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-512971
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Üstün Alkan, Fulya…[et al.]. The Effects of Piroxicam and Deracoxib on Canine Mammary Tumour Cell Line. The Scientific World Journal No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-512971
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Üstün Alkan, Fulya& Üstüner, Oya& Bakırel, Tülay& Çınar, Suzan& Erten, Gaye& Deniz, Günnur. The Effects of Piroxicam and Deracoxib on Canine Mammary Tumour Cell Line. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-512971
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-512971
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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