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Reversal of Myoblast Aging by Tocotrienol Rich Fraction Posttreatment
المؤلفون المشاركون
Wan Ngah, Wan Zurinah
Mouly, Vincent
Lim, Jing Jye
Abdul Karim, Norwahidah
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Skeletal muscle satellite cells are heavily involved in the regeneration of skeletal muscle in response to the aging-related deterioration of the skeletal muscle mass, strength, and regenerative capacity, termed as sarcopenia.
This study focused on the effect of tocotrienol rich fraction (TRF) on regenerative capacity of myoblasts in stress-induced premature senescence (SIPS).
The myoblasts was grouped as young control, SIPS-induced, TRF control, TRF pretreatment, and TRF posttreatment.
Optimum dose of TRF, morphological observation, activity of senescence-associated β-galactosidase (SA-β-galactosidase), and cell proliferation were determined.
50 μg/mL TRF treatment exhibited the highest cell proliferation capacity.
SIPS-induced myoblasts exhibit large flattened cells and prominent intermediate filaments (senescent-like morphology).
The activity of SA-β-galactosidase was significantly increased, but the proliferation capacity was significantly reduced as compared to young control.
The activity of SA-β-galactosidase was significantly reduced and cell proliferation was significantly increased in the posttreatment group whereas there was no significant difference in SA-β-galactosidase activity and proliferation capacity of pretreatment group as compared to SIPS-induced myoblasts.
Based on the data, we hypothesized that TRF may reverse the myoblasts aging through replenishing the regenerative capacity of the cells.
However, further investigation on the mechanism of TRF in reversing the myoblast aging is needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lim, Jing Jye& Wan Ngah, Wan Zurinah& Mouly, Vincent& Abdul Karim, Norwahidah. 2013. Reversal of Myoblast Aging by Tocotrienol Rich Fraction Posttreatment. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-513011
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lim, Jing Jye…[et al.]. Reversal of Myoblast Aging by Tocotrienol Rich Fraction Posttreatment. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-513011
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lim, Jing Jye& Wan Ngah, Wan Zurinah& Mouly, Vincent& Abdul Karim, Norwahidah. Reversal of Myoblast Aging by Tocotrienol Rich Fraction Posttreatment. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-513011
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513011
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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