The Role of PinX1 in Growth Control of Breast Cancer Cells and Its Potential Molecular Mechanism by mRNA and lncRNA Expression Profiles Screening
المؤلفون المشاركون
Shi, Rong
Zhao, Zhen
Zheng, Wen-Ling
Zhou, Jue-Yu
Zhou, Hui
Liang, Sang-Hua
Ma, Wen-Li
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
As a major tumor suppressor gene, the role of PinX1 in breast cancer and its molecular mechanism remain unclear.
In this study, overexpression of PinX1 was generated in 3 breast cancer cell lines, and knockdown of PinX1 was performed in a nontumorigenic breast cell line.
The regulation of PinX1 on cell proliferation and cell cycle was observed.
A microarray-based lncRNA and mRNA expression profile screening was also performed.
We found a lower growth rate, G0/G1 phase arrest, and S phase inhibition in the PinX1 overexpressed breast cancer cells, while a higher growth rate, decreased G0/G1 phase, and increased S phase rate in the PinX1 knocked-down nontumorigenic breast cell.
A total of 977 mRNAs and 631 lncRNAs were identified as differentially expressed transcripts between PinX1 overexpressed and control MCF-7 cells.
Further analysis identified the involvement of these mRNAs in 52 cancer related pathways and various other biological processes.
11 enhancer-like lncRNAs and 25 lincRNAs with their adjacent mRNA pairs were identified as coregulated transcripts.
Our results confirmed the role of PinX1 as a major tumor suppressor gene in breast cancer cell lines and provided information for further research on the molecular mechanisms of PinX1 in tumorigenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shi, Rong& Zhou, Jue-Yu& Zhou, Hui& Zhao, Zhen& Liang, Sang-Hua& Zheng, Wen-Ling…[et al.]. 2014. The Role of PinX1 in Growth Control of Breast Cancer Cells and Its Potential Molecular Mechanism by mRNA and lncRNA Expression Profiles Screening. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-513094
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shi, Rong…[et al.]. The Role of PinX1 in Growth Control of Breast Cancer Cells and Its Potential Molecular Mechanism by mRNA and lncRNA Expression Profiles Screening. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-513094
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shi, Rong& Zhou, Jue-Yu& Zhou, Hui& Zhao, Zhen& Liang, Sang-Hua& Zheng, Wen-Ling…[et al.]. The Role of PinX1 in Growth Control of Breast Cancer Cells and Its Potential Molecular Mechanism by mRNA and lncRNA Expression Profiles Screening. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-513094
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513094
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر