Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity
المؤلفون المشاركون
Kunz, Manfred
Ibrahim, Saleh M.
المصدر
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-10-26
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
The precise pathomechanisms of human autoimmune diseases are still poorly understood.
However, a deepened understanding of these is urgently needed to improve disease prevention and early detection and guide more specific treatment approaches.
In recent years, many new genes and signalling pathways involved in autoimmunity with often overlapping patterns between different disease entities have been detected.
Major contributions were made by experiments using DNA microarray technology, which has been used for the analysis of gene expression patterns in chronic inflammatory and autoimmune diseases, among which were rheumatoid arthritis, systemic lupus erythematosus, psoriasis, systemic sclerosis, multiple sclerosis, and type-1 diabetes.
In systemic lupus erythematosus, a so-called interferon signature has been identified.
In psoriasis, researchers found a particular immune signalling cluster.
Moreover the identification of a new subset of inflammatory T cells, so-called Th17 T cells, secreting interleukin (IL)-17 as one of their major cytokines and the identification of the IL-23/IL-17 axis of inflammation regulation, have significantly improved our understanding of autoimmune diseases.
Since a plethora of new treatment approaches using antibodies or small molecule inhibitors specifically targeting cytokines, cellular receptors, or signalling mechanisms has emerged in recent years, more individualized treatment for affected patients may be within reach in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kunz, Manfred& Ibrahim, Saleh M.. 2009. Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-20.
https://search.emarefa.net/detail/BIM-513113
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kunz, Manfred& Ibrahim, Saleh M.. Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity. Mediators of Inflammation No. 2009 (2009), pp.1-20.
https://search.emarefa.net/detail/BIM-513113
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kunz, Manfred& Ibrahim, Saleh M.. Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-20.
https://search.emarefa.net/detail/BIM-513113
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513113
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر