Cysticerci Drive Dendritic Cells to Promote In Vitro and In Vivo Tregs Differentiation
المؤلفون المشاركون
Adalid-Peralta, Laura
Arce-Sillas, Asiel
Sciutto, Edda
Fleury, Agnes
Casanova-Hernández, Didier
Rangel-Escareño, Claudia
Uribe-Figueroa, Laura
Cárdenas, Graciela
Rosetti, Marcos
Fragoso, Gladis
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Regulatory T cells (Tregs) play a crucial role in immune homeostasis.
Treg induction is a strategy that parasites have evolved to modulate the host’s inflammatory environment, facilitating their establishment and permanence.
In human Taenia solium neurocysticercosis (NC), the concurrence of increased peripheral and central Treg levels and their capacity to inhibit T cell activation and proliferation support their role in controlling neuroinflammation.
This study is aimed at identifing possible mechanisms of Treg induction in human NC.
Monocyte-derived dendritic cells (DC) from healthy human donors, cocultivated with autologous CD4+ naïve cells either in the presence or absence of cysticerci, promoted CD25highFoxp3+ Treg differentiation.
An increased Treg induction was observed when cysticerci were present.
Moreover, an augmentation of suppressive-related molecules (SLAMF1, B7-H1, and CD205) was found in parasite-induced DC differentiation.
Increased Tregs and a higher in vivo DC expression of the regulatory molecules SLAMF1 and CD205 in NC patients were also found.
SLAMF1 gene was downregulated in NC patients with extraparenchymal cysticerci, exhibiting higher inflammation levels than patients with parenchymal parasites.
Our findings suggest that cysticerci may modulate DC to favor a suppressive environment, which may help parasite establishment, minimizing the excessive inflammation, which may lead to tissue damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Adalid-Peralta, Laura& Arce-Sillas, Asiel& Fragoso, Gladis& Cárdenas, Graciela& Rosetti, Marcos& Casanova-Hernández, Didier…[et al.]. 2013. Cysticerci Drive Dendritic Cells to Promote In Vitro and In Vivo Tregs Differentiation. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-513300
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Adalid-Peralta, Laura…[et al.]. Cysticerci Drive Dendritic Cells to Promote In Vitro and In Vivo Tregs Differentiation. Clinical and Developmental Immunology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-513300
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Adalid-Peralta, Laura& Arce-Sillas, Asiel& Fragoso, Gladis& Cárdenas, Graciela& Rosetti, Marcos& Casanova-Hernández, Didier…[et al.]. Cysticerci Drive Dendritic Cells to Promote In Vitro and In Vivo Tregs Differentiation. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-513300
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513300
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر