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Royal Jelly Modulates Oxidative Stress and Apoptosis in Liver and Kidneys of Rats Treated with Cisplatin
المؤلفون المشاركون
Kisa, Fikrullah
Turkeli, Mehmet
Karakus, Emre
Yildirim, Serap
Can, Ismail
Kara, Adem
Karadeniz, Ali
Emre, Habib
Simsek, Nejdet
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-08-01
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Cisplatin (CDDP) is one of the most active cytotoxic agents in the treatment of cancer and has adverse side effects such as nephrotoxicity and hepatotoxicity.
The present study was designed to determine the effects of royal jelly (RJ) against oxidative stress caused by CDDP injury of the kidneys and liver, by measuring tissue biochemical and antioxidant parameters and investigating apoptosis immunohistochemically.
Twenty-four Sprague Dawley rats were divided into four groups, group C: control group received 0.9% saline; group CDDP: injected i.p.
with cisplatin (CDDP, 7 mg kg-1 body weight i.p., single dose); group RJ: treated for 15 consecutive days by gavage with RJ (300 mg/kg/day); group RJ + CDDP: treated by gavage with RJ 15 days following a single injection of CDDP.
Malondialdehyde (MDA) and glutathione (GSH) levels, glutathione S-transferase (GST), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activities were determined in liver and kidney homogenates, and the liver and kidney were also histologically examined.
RJ elicited a significant protective effect towards liver and kidney by decreasing the level of lipid peroxidation (MDA), elevating the level of GSH, and increasing the activities of GST, GSH-Px, and SOD.
In the immunohistochemical examinations were observed significantly enhanced apoptotic cell numbers and degenerative changes by cisplatin, but these histological changes were lower in the liver and kidney tissues of RJ + CDDP group.
Besides, treatment with RJ lead to an increase in antiapoptotic activity hepatocytes and tubular epithelium.
In conclusion, RJ may be used in combination with cisplatin in chemotherapy to improve cisplatin-induced oxidative stress parameters and apoptotic activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Karadeniz, Ali& Simsek, Nejdet& Karakus, Emre& Yildirim, Serap& Kara, Adem& Can, Ismail…[et al.]. 2011. Royal Jelly Modulates Oxidative Stress and Apoptosis in Liver and Kidneys of Rats Treated with Cisplatin. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-513342
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Karadeniz, Ali…[et al.]. Royal Jelly Modulates Oxidative Stress and Apoptosis in Liver and Kidneys of Rats Treated with Cisplatin. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-513342
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Karadeniz, Ali& Simsek, Nejdet& Karakus, Emre& Yildirim, Serap& Kara, Adem& Can, Ismail…[et al.]. Royal Jelly Modulates Oxidative Stress and Apoptosis in Liver and Kidneys of Rats Treated with Cisplatin. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-513342
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513342
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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