Mechanical and Electrophysiological Properties of the Sarcolemma of Muscle Fibers in Two Murine Models of Muscle Dystrophy : Col6a1−− and Mdx
المؤلفون المشاركون
Reggiani, Carlo
Raiteri, R.
Canato, M.
Vassanelli, S.
Dal Maschio, M.
Megighian, A.
Sbrana, F.
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-04-08
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
This study aimed to analyse the sarcolemma of Col6a1−/− fibers in comparison with wild type and mdx fibers, taken as positive control in view of the known structural and functional alterations of their membranes.
Structural and mechanical properties were studied in single muscle fibers prepared from FDB muscle using atomic force microscopy (AFM) and conventional electrophysiological techniques to measure ionic conductance and capacitance.
While the sarcolemma topography was preserved in both types of dystrophic fibers, membrane elasticity was significantly reduced in Col6a1−/− and increased in mdx fibers.
In the membrane of Col6a1−/− fibers ionic conductance was increased likely due to an increased leakage, whereas capacitance was reduced, and the action potential (ap) depolarization rate was reduced.
The picture emerging from experiments on fibers in culture was consistent with that obtained on intact freshly dissected muscle.
Mdx fibers in culture showed a reduction of both membrane conductance and capacitance.
In contrast, in mdx intact FDB muscle resting conductance was increased while resting potential and ap depolarization rate were reduced, likely indicating the presence of a consistent population of severely altered fibers which disappear during the culture preparation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Canato, M.& Dal Maschio, M.& Sbrana, F.& Raiteri, R.& Reggiani, Carlo& Vassanelli, S.…[et al.]. 2010. Mechanical and Electrophysiological Properties of the Sarcolemma of Muscle Fibers in Two Murine Models of Muscle Dystrophy : Col6a1−− and Mdx. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-513352
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Canato, M.…[et al.]. Mechanical and Electrophysiological Properties of the Sarcolemma of Muscle Fibers in Two Murine Models of Muscle Dystrophy : Col6a1−− and Mdx. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-513352
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Canato, M.& Dal Maschio, M.& Sbrana, F.& Raiteri, R.& Reggiani, Carlo& Vassanelli, S.…[et al.]. Mechanical and Electrophysiological Properties of the Sarcolemma of Muscle Fibers in Two Murine Models of Muscle Dystrophy : Col6a1−− and Mdx. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-513352
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513352
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر