VEGF and eNOS Expression in Umbilical Cord from Pregnancy Complicated by Hypertensive Disorder with Different Severity
المؤلفون المشاركون
Bhavina, K.
Pandian, S. Sundara
Radhika, J.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-14
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Reduced blood flow in hypertensive pregnancy may influence the production vasoconstrictors; subsequently the vessel remains in highly contracted state.
NO is a vasodilator; VEGF influences its synthesis by regulating eNOS production.
Aim of our study was to evaluate the expression of VEGF and eNOS in different severity of hypertensive pregnancy.
Methods.
Study was conducted in 4 groups with 40 members: group 1—control, group 2—gestational hypertension, group 3—mild preeclampsia, and group 4—severe preeclampsia.
Fetal end of umbilical cord was taken and follows IHC staining protocol for VEGF and eNOS antibody.
Staining intensity were measured by semiquantitative scoring method.
Mann Whitney U test was used to compare each group.
Results.
Decreased expression of both VEGF and eNOS was found in hypertensive condition than in normal condition.
Among hypertensive group, severe preeclamptic group showed more intensity in staining than gestational hypertension and mild preeclampsia.
Conclusion.
Reduction of VEGF and eNOS in gestational hypertension may lead to hypoperfusion and subsequent hypoxia of fetus in hypertensive pregnancy.
The developed hypoxic state may upregulate the synthesis of VEGF and thereby eNOS.
Increased expression of VEGF and eNOS in severe group may be a compensatory mechanism to dilate the blood vessels and to improve blood flow of fetus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bhavina, K.& Radhika, J.& Pandian, S. Sundara. 2014. VEGF and eNOS Expression in Umbilical Cord from Pregnancy Complicated by Hypertensive Disorder with Different Severity. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-513373
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bhavina, K.…[et al.]. VEGF and eNOS Expression in Umbilical Cord from Pregnancy Complicated by Hypertensive Disorder with Different Severity. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-513373
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bhavina, K.& Radhika, J.& Pandian, S. Sundara. VEGF and eNOS Expression in Umbilical Cord from Pregnancy Complicated by Hypertensive Disorder with Different Severity. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-513373
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513373
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر