Immunological Aspects in Late Phase of Living Donor Liver Transplant Patients : Usefulness of Monitoring Peripheral Blood CD4+ Adenosine Triphosphate Activity
المؤلفون المشاركون
Okuda, Masahiro
Nobori, Tsutomu
Mizuno, Shugo
Shiraki, Katsuya
Yamada, Tomomi
Tanemura, Akihiro
Kishiwada, Masashi
Ohsawa, Ichiro
Kuriyama, Naohisa
Yamamoto, Norihiko
Tabata, Masami
Isaji, Shuji
Sakurai, Hiroyuki
Nakatani, Kaname
Muraki, Yuichi
Azumi, Yoshinori
Takei, Yoshiyuki
Usui, Masanobu
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
To evaluate whether the combination of the peripheral blood CD4+ adenosine triphosphate activity (ATP) assay (ImmuKnow assay: IMK assay) and cytochrome P450 3A5 (CYP3A5) genotype assay is useful for monitoring of immunological aspects in the patient followup of more than one year after living donor liver transplantation (LDLT).
Methods.
Forty-nine patients, who underwent LDLT more than one year ago, were randomly screened by using IMK assay from January 2010 to December 2011, and the complete medical records of each patient were obtained.
The CYP3A5 genotypes were examined in thirty-nine patients of them.
Results.
The mean ATP level of the IMK assay was significantly lower in the patients with infection including recurrence of hepatitis C (HCV) (n=10) than in those without infection (n=39): 185 versus 350 ng/mL (P<0.001), while it was significantly higher in the patients with rejection (n=4) than in those without rejection (n=45): 663 versus 306 ng/mL (P<0.001).
The IMK assay showed favorable sensitivity/specificity for infection (0.909/0.842) as well as acute rejection (1.0/0.911).
CYP3A5 genotypes in both recipient and donor did not affect incidence of infectious complications.
Conclusions.
In the late phase of LDLT patients, the IMK assay is very useful for monitoring immunological aspects including bacterial infection, recurrence of HCV, and rejection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mizuno, Shugo& Muraki, Yuichi& Nakatani, Kaname& Tanemura, Akihiro& Kuriyama, Naohisa& Ohsawa, Ichiro…[et al.]. 2013. Immunological Aspects in Late Phase of Living Donor Liver Transplant Patients : Usefulness of Monitoring Peripheral Blood CD4+ Adenosine Triphosphate Activity. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-513374
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mizuno, Shugo…[et al.]. Immunological Aspects in Late Phase of Living Donor Liver Transplant Patients : Usefulness of Monitoring Peripheral Blood CD4+ Adenosine Triphosphate Activity. Clinical and Developmental Immunology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-513374
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mizuno, Shugo& Muraki, Yuichi& Nakatani, Kaname& Tanemura, Akihiro& Kuriyama, Naohisa& Ohsawa, Ichiro…[et al.]. Immunological Aspects in Late Phase of Living Donor Liver Transplant Patients : Usefulness of Monitoring Peripheral Blood CD4+ Adenosine Triphosphate Activity. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-513374
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513374
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر