![](/images/graphics-bg.png)
VEGF in the Crosstalk between Human Adipocytes and Smooth Muscle Cells : Depot-Specific Release from Visceral and Perivascular Adipose Tissue
المؤلفون المشاركون
Greulich, Sabrina
Knoefel, Wolfram Trudo
Willems, Miriam
Maxhera, Bujar
Ruppe, Florian
Sell, Henrike
Lichtenberg, Artur
Schlich, Raphaela
Ouwens, D. Margriet
Eckel, Jürgen
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Adipose tissue secrets adipokines and fatty acids, which may contribute to obesity-associated vascular dysfunction and cardiovascular risk.
This study investigated which factors are responsible for the synergistic effect of adipokine and oleic acid- (OA-) induced proliferation of human vascular smooth muscle cells (VSMC).
Adipocyte-conditioned medium (CM) from human adipocytes induces proliferation of VSMC in correlation to its vascular endothelial growth factor (VEGF) content.
CM increases VEGF-receptor (VEGF-R) 1 and 2 expression and VEGF secretion of VSMC, while OA only stimulates VEGF secretion.
VEGF neutralization abrogates CM- and OA-induced proliferation and considerably reduces proliferation induced by CM and OA in combination.
VEGF release is higher from visceral adipose tissue (VAT) of obese subjects compared to subcutaneous adipose tissue (SAT) and VAT from lean controls.
Furthermore, VEGF release from VAT correlates with its proliferative effect.
Perivascular adipose tissue (PAT) from type 2 diabetic patients releases significantly higher amounts of VEGF and induces stronger proliferation of VSMC as compared to SAT and SAT/PAT of nondiabetics.
In conclusion, VEGF is mediating CM-induced proliferation of VSMC.
As this adipokine is released in high amounts from VAT of obese patients and PAT of diabetic patients, VEGF might link adipose tissue inflammation to increased VSMC proliferation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schlich, Raphaela& Willems, Miriam& Greulich, Sabrina& Ruppe, Florian& Knoefel, Wolfram Trudo& Ouwens, D. Margriet…[et al.]. 2013. VEGF in the Crosstalk between Human Adipocytes and Smooth Muscle Cells : Depot-Specific Release from Visceral and Perivascular Adipose Tissue. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-513397
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schlich, Raphaela…[et al.]. VEGF in the Crosstalk between Human Adipocytes and Smooth Muscle Cells : Depot-Specific Release from Visceral and Perivascular Adipose Tissue. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-513397
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schlich, Raphaela& Willems, Miriam& Greulich, Sabrina& Ruppe, Florian& Knoefel, Wolfram Trudo& Ouwens, D. Margriet…[et al.]. VEGF in the Crosstalk between Human Adipocytes and Smooth Muscle Cells : Depot-Specific Release from Visceral and Perivascular Adipose Tissue. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-513397
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513397
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)