Substituting Doxorubicin with Nonpegylated Liposomal Doxorubicin for the Treatment of Early Breast Cancer : Results of a Retrospective Study
المؤلفون المشاركون
Camburn, Teresa
Houghton, David
Davidson, Neville
Keary, Ian
المصدر
International Journal of Breast Cancer
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-12
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Introduction.
Evidence from the metastatic setting suggests that replacing conventional doxorubicin with nonpegylated liposomal doxorubicin (NPLD) for early breast cancer may maintain efficacy whilst reducing long-term cardiotoxicity, an important consideration with many patients going on to receive multiple lines of treatment.
Methods.
Consecutive patients with early breast cancer treated with NPLD were assessed for disease progression and changes in cardiac function according to left ventricular ejection fraction (LVEF).
Results.
Ninety-seven patients (median age at diagnosis 51 (32–76) years) were studied.
The majority received NPLD (60 mg/m2 plus cyclophosphamide 600 mg/m2) adjuvantly (79.4%) and in sequence with a taxane (79.4%; docetaxel 75 mg/m2).
80.4% had radiotherapy and 15.5% received trastuzumab.
Mean time to disease recurrence was 87.0 months (80.7–93.2 [95% confidence interval]) and 5-year disease-free survival was 86.0%.
Mean LVEF values remained within the normal range of ≥55% during treatment and throughout the cardiac follow-up period (median 7 months, range 1–21 months).
Use of trastuzumab and age at diagnosis did not appear to influence LVEF.
Conclusion.
NPLD appeared to be a well-tolerated substitute for conventional doxorubicin in patients with early breast cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Davidson, Neville& Camburn, Teresa& Keary, Ian& Houghton, David. 2014. Substituting Doxorubicin with Nonpegylated Liposomal Doxorubicin for the Treatment of Early Breast Cancer : Results of a Retrospective Study. International Journal of Breast Cancer،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-513553
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Davidson, Neville…[et al.]. Substituting Doxorubicin with Nonpegylated Liposomal Doxorubicin for the Treatment of Early Breast Cancer : Results of a Retrospective Study. International Journal of Breast Cancer No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-513553
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Davidson, Neville& Camburn, Teresa& Keary, Ian& Houghton, David. Substituting Doxorubicin with Nonpegylated Liposomal Doxorubicin for the Treatment of Early Breast Cancer : Results of a Retrospective Study. International Journal of Breast Cancer. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-513553
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513553
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر