Cell Polarity, Epithelial-Mesenchymal Transition, and Cell-Fate Decision Gene Expression in Ductal Carcinoma In Situ
المؤلفون المشاركون
Boracchi, Patrizia
Ambrogi, Federico
Coradini, Danila
Biganzoli, Elia
Oriana, Saro
المصدر
International Journal of Surgical Oncology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Loss of epithelial cell identity and acquisition of mesenchymal features are early events in the neoplastic transformation of mammary cells.
We investigated the pattern of expression of a selected panel of genes associated with cell polarity and apical junction complex or involved in TGF-β-mediated epithelial-mesenchymal transition and cell-fate decision in a series of DCIS and corresponding patient-matched normal tissue.
Additionally, we compared DCIS gene profile with that of atypical ductal hyperplasia (ADH) from the same patient.
Statistical analysis identified a “core” of genes differentially expressed in both precursors with respect to the corresponding normal tissue mainly associated with a terminally differentiated luminal estrogen-dependent phenotype, in agreement with the model according to which ER-positive invasive breast cancer derives from ER-positive progenitor cells, and with an autocrine production of estrogens through androgens conversion.
Although preliminary, present findings provide transcriptomic confirmation that, at least for the panel of genes considered in present study, ADH and DCIS are part of a tumorigenic multistep process and strongly arise the necessity for the regulation, maybe using aromatase inhibitors, of the intratumoral and/or circulating concentration of biologically active androgens in DCIS patients to timely hamper abnormal estrogens production and block estrogen-induced cell proliferation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Coradini, Danila& Boracchi, Patrizia& Ambrogi, Federico& Biganzoli, Elia& Oriana, Saro. 2012. Cell Polarity, Epithelial-Mesenchymal Transition, and Cell-Fate Decision Gene Expression in Ductal Carcinoma In Situ. International Journal of Surgical Oncology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-513589
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Coradini, Danila…[et al.]. Cell Polarity, Epithelial-Mesenchymal Transition, and Cell-Fate Decision Gene Expression in Ductal Carcinoma In Situ. International Journal of Surgical Oncology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-513589
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Coradini, Danila& Boracchi, Patrizia& Ambrogi, Federico& Biganzoli, Elia& Oriana, Saro. Cell Polarity, Epithelial-Mesenchymal Transition, and Cell-Fate Decision Gene Expression in Ductal Carcinoma In Situ. International Journal of Surgical Oncology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-513589
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513589
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر