Arrabidaea chica Hexanic Extract Induces Mitochondrion Damage and Peptidase Inhibition on Leishmania spp.
المؤلفون المشاركون
Alviano, Daniela S.
Alviano, Celuta S.
Rodrigues, Igor A.
Vermelho, Alane Beatriz
Azevedo, Mariana M. B.
Chaves, Francisco C. M.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Currently available leishmaniasis treatments are limited due to severe side effects.
Arrabidaea chica is a medicinal plant used in Brazil against several diseases.
In this study, we investigated the effects of 5 fractions obtained from the crude hexanic extract of A.
chica against Leishmania amazonensis and L.
infantum, as well as on the interaction of these parasites with host cells.
Promastigotes were treated with several concentrations of the fractions obtained from A.
chica for determination of their minimum inhibitory concentration (MIC).
In addition, the effect of the most active fraction (B2) on parasite’s ultrastructure was analyzed by transmission electron microscopy.
To evaluate the inhibitory activity of B2 fraction on Leishmania peptidases, parasites lysates were treated with the inhibitory and subinhibitory concentrations of the B2 fraction.
The minimum inhibitory concentration of B2 fraction was 37.2 and 18.6 μg/mL for L.
amazonensis and L.
infantum, respectively.
Important ultrastructural alterations as mitochondrial swelling with loss of matrix content and the presence of vesicles inside this organelle were observed in treated parasites.
Moreover, B2 fraction was able to completely inhibit the peptidase activity of promastigotes at pH 5.5.
The results presented here further support the use of A.
chica as an interesting source of antileishmanial agents.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rodrigues, Igor A.& Azevedo, Mariana M. B.& Chaves, Francisco C. M.& Alviano, Celuta S.& Alviano, Daniela S.& Vermelho, Alane Beatriz. 2014. Arrabidaea chica Hexanic Extract Induces Mitochondrion Damage and Peptidase Inhibition on Leishmania spp.. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-513684
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rodrigues, Igor A.…[et al.]. Arrabidaea chica Hexanic Extract Induces Mitochondrion Damage and Peptidase Inhibition on Leishmania spp.. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-513684
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rodrigues, Igor A.& Azevedo, Mariana M. B.& Chaves, Francisco C. M.& Alviano, Celuta S.& Alviano, Daniela S.& Vermelho, Alane Beatriz. Arrabidaea chica Hexanic Extract Induces Mitochondrion Damage and Peptidase Inhibition on Leishmania spp.. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-513684
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513684
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر