Increased IL-33 in Synovial Fluid and Paired Serum Is Associated with Disease Activity and Autoantibodies in Rheumatoid Arthritis
المؤلفون المشاركون
Guo, Jianping
Mu, Rong
Hu, Fanlei
Jiang, Huirong
Li, Zhanguo
Zhou, Wei
Huang, Heqing
Tang, Sumei
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-09
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objectives.
IL-33, a newly found cytokine which is involved in joint inflammation, could be blocked by a decoy receptor—sST2.
The expression and correlation of IL-33 and sST2 in rheumatoid arthritis (RA) are of great interest.
Methods.
Synovial fluid (SF) was obtained from 120 RA and 30 osteoarthritis (OA) patients, and paired sera were collected from 54 of these RA patients.
The levels of IL-33 and sST2 were measured by ELISA.
Results.
SF IL-33 was significantly higher in RA than in OA, which was correlated with disease activity score 28, erythrocyte sedimentation rate, rheumatoid factor (RF)-IgM, RF-IgG, glucose phosphate isomerase (GPI), and immunoglobulin.
Serum IL-33 was correlated positively with SF IL-33 in RA.
Furthermore, it was correlated with RF-IgM and GPI.
sST2 was partly detectable in RA (13 out of 54, 24.1%), while not in OA.
Serum sST2 in RA had no significant correlation with serum IL-33 or SF IL-33.
However, SFs from both RA and OA patients did not express sST2.
Conclusions.
This study supported that IL-33 played an important role in the local pathogenesis of RA.
Considering the tight correlation between IL-33 and clinical features, it may become a new target of local treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tang, Sumei& Huang, Heqing& Hu, Fanlei& Zhou, Wei& Guo, Jianping& Jiang, Huirong…[et al.]. 2013. Increased IL-33 in Synovial Fluid and Paired Serum Is Associated with Disease Activity and Autoantibodies in Rheumatoid Arthritis. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-513698
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Sumei…[et al.]. Increased IL-33 in Synovial Fluid and Paired Serum Is Associated with Disease Activity and Autoantibodies in Rheumatoid Arthritis. Clinical and Developmental Immunology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-513698
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tang, Sumei& Huang, Heqing& Hu, Fanlei& Zhou, Wei& Guo, Jianping& Jiang, Huirong…[et al.]. Increased IL-33 in Synovial Fluid and Paired Serum Is Associated with Disease Activity and Autoantibodies in Rheumatoid Arthritis. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-513698
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513698
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر