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Modulation of Wolframin Expression in Human Placenta during Pregnancy : Comparison among Physiological and Pathological States
المؤلفون المشاركون
De Luca, Antonio
Cobellis, Luigi
Iannaccone, Alessandro
Perna, Angelica
Lucariello, Angela
De Falco, Maria
Sellitto, Carmine
Baldi, Alfonso
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-23
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The WFS1 gene, encoding a transmembrane glycoprotein of the endoplasmic reticulum called wolframin, is mutated in Wolfram syndrome, an autosomal recessive disorder defined by the association of diabetes mellitus, optic atrophy, and further organ abnormalities.
Disruption of the WFS1 gene in mice causes progressive β-cell loss in the pancreas and impaired stimulus-secretion coupling in insulin secretion.
However, little is known about the physiological functions of this protein.
We investigated the immunohistochemical expression of wolframin in human placenta throughout pregnancy in normal women and diabetic pregnant women.
In normal placenta, there was a modulation of wolframin throughout pregnancy with a strong level of expression during the first trimester and a moderate level in the third trimester of gestation.
In diabetic women, wolframin expression was strongly reduced in the third trimester of gestation.
The pattern of expression of wolframin in normal placenta suggests that this protein may be required to sustain normal rates of cytotrophoblast cell proliferation during the first trimester of gestation.
The decrease in wolframin expression in diabetic placenta suggests that this protein may participate in maintaining the physiologic glucose homeostasis in this organ.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lucariello, Angela& Perna, Angelica& Sellitto, Carmine& Baldi, Alfonso& Iannaccone, Alessandro& Cobellis, Luigi…[et al.]. 2014. Modulation of Wolframin Expression in Human Placenta during Pregnancy : Comparison among Physiological and Pathological States. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-513712
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lucariello, Angela…[et al.]. Modulation of Wolframin Expression in Human Placenta during Pregnancy : Comparison among Physiological and Pathological States. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-513712
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lucariello, Angela& Perna, Angelica& Sellitto, Carmine& Baldi, Alfonso& Iannaccone, Alessandro& Cobellis, Luigi…[et al.]. Modulation of Wolframin Expression in Human Placenta during Pregnancy : Comparison among Physiological and Pathological States. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-513712
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513712
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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